妊娠期肾病综合征的临床分析

Clinical Analysis of Nephritic Syndrome of Pregnancy

目的 分析妊娠期肾病综合征 (NSP)的临床特点 ,诊断及治疗。方法 回顾分析 42 9例妊高征病例临床资料 ,将重度妊高征 76例中合并肾病综合征 19例 (肾病组 )与无合并肾病综合征 5 7例 (对照组 )进行对比分析。结果 肾病组血清总蛋白、白蛋白比对照组低 (P<0 .0 0 1)。肾病组 2 4h尿蛋白 ,肌酐比对照组高 (P<0 .0 0 1)。两组尿酸水平高于正常值 ,肾病组腹水、胸水、脑水肿、SGA发生率高于对照组。围产儿死亡率高于对照组。结论 妊娠期肾病综合征是妊高征另一特殊类型 ,应在治疗妊高征基础上 ,综合治疗 ,否则将影响疗效 ,导致母婴并发症增加。

Objective To investigate the clinical Characteristics,diagnosis and treatment of the nezhritic syndrome pregnacy(NSP).Methods From 1995～2002,a total of 429 patients with pregnancy-induced hyertension(PIH)were retrospectivly analyzed.76 cases of severe PIH were divided into nephritic group(19 cases) and control group(57 cases),and comparision between the two groups was conducted.Results In the NSP group,the maternal serum total protein and albumin were lower than those in control group(P<0.001).In nephritic group urine albumin in 24 hours and creatinine were higher than those in control group(P<0.001).The uric acid in tow groups were higher than normal.The ascites,pleuritic fluid,cerebral edma,SGA,the mortality of perinatal fetal in NSP group were higher than those in control group.Conclusion NSP was a special PIH.Multipurpose therapy should be done based on therapy for PIH.