摘要
近视是一种发育性疾病 ,近视眼球巩膜的主动扩张是其伸长的重要机制 ,而视黄醛是眼球发育中重要的信号转导分子 ,其在脊椎动物的眼球发育中具有多种不同的重要作用。视黄醛可能是调节实验性近视眼球伸长的信使分子。近年来有关视黄醛与实验性近视发生、发展的关系的研究取得一定进展 ,本研究综述了视黄醛及其核受体、实验性近视眼球的视网膜、脉络膜、巩膜的视黄醛改变以及视黄醛作为传递从视网膜到巩膜的眼球伸长信号的信使分子的研究进展情况。
Myopia is an abnormality in development and excessive elongation of the eye that is mainly due to the active extension of the sclera. Retinoic acid is an important signaling molecule in the developing eye;it plays several important roles in the process of ocular development. Retinoic acid may be the mediator between the retina and sclera. Progress has been made in research about the relationship between retinoic acid and experimental myopia in the last few years. This paper summarizes the results of research on retinoic acid and its nuclear receptors as they relate to changes in the retina,choroid and sclera in the experimental myopic eye and its role as the signaling molecule between retina and sclera during ocular elongation.
出处
《眼视光学杂志》
2003年第1期55-57,共3页
Chinese Journal of Optometry & Ophthalmology
