出生后不同时间应用沐舒坦预防早产儿肺透明膜病的临床观察

Effect on the prevention of hyaline membrane disease in premature newborns by using Mucosolvan at different times

目的 探讨早产儿出生后不同时间开始应用沐舒坦预防肺透明膜病 (HMD)的效果。方法 15 0例胎龄≤ 36周的早产儿入院后均给予沐舒坦 30mg·kg- 1 ·d- 1 ,分 2～ 4次静脉滴注 ,并分别按用药距出生时间分为～ 1h、～ 6h、～ 12h、～ 2 4h 4组 ,观察其发生HMD的情况 ,并与对照组进行比较分析。结果 1)观察组 15 0例中发生HMD 14例 (9 33% ) ,对照组 15 0例中发生HMD 2 6例 (16 6 7% ,P <0 0 5 ) ;2 )出生后不同时间开始应用沐舒坦 ,在 1h内及 1～ 6h用药者 ,HMD的发生率分别为 3 2 2 %和 6 0 6 % ,与对照组比较均P <0 0 5 ;而 6～ 12h及 12～ 2 4h用药者 ,HMD的发生率分别率为 14 81%及 19 2 3% ,与对照组比较均P >0 0 5。结论 早产儿出生后及早应用沐舒坦预防HMD有良好效果 ,但用药时机必须掌握在出生后 6h内 ,超过

Objective To study the effect on prevention of hyaline membrane disease(HMD)in premature newborns by using Mucosolvan at different times.Methods 150 premature infants with HMD were treated with Mucosolvan 30mg·kg -1 ·d -1 ,given at different times after birth:<1h,<6h,<12h,<24h,the results were compared with control group.Results (1)14 out of 150 infants in the Mucosolvan group developed HMD,occurrence rate was 9 33%.Compared with control group,26 developed HMD with rate of 16 69%.The difference was significant( χ 2=4 15, P <0 05);(2)Comparing different treatment times,those treated within 1 or 6 hours,the HMD occurrence rates were 3 22% and 6 06% respectively.There was significant difference compared with control group( P <0 05).The rates were 14 81% and 19 23% among the infants treated from 6～12 h or 12～24 h,the differences were not significant( P >0 05).Conclusion Defininte effect can be achieved by using Mucosolvan to prevent HMD in premature infants,but should be used within 6 hours after birth. [