深部真菌感染患者血清葡聚糖检测的临床意义

Clinical Significance of Serum (1→3)β-D Glucan Measurement in Diagnosis of Deep Mycosis

目的 探讨血清葡聚糖检测在真菌感染早期诊断中的实用价值。方法 以定量鲎试验检测了 5 4例健康人和 6 0例真菌感染患者血清葡聚糖含量 ,同时检测了相应的真菌抗原和抗体。结果 不同真菌感染组的血清葡聚糖浓度虽有差别 ,但均与对照组有显著性差异 (P<0 .0 5 ) ,其用于真菌感染早期诊断的敏感度大大高于真菌抗原和抗体检测。结论 血清葡聚糖检测是一种实用的深部真菌感染早期诊断方法。

Objective To explore clinical significance of serum (1→3)β D glucan measurement in early diagnosis of deep mycosis.Methods sera (1→3)β D glucan measurement were performed in 54 normal persons and 60 deep mycosis patients with quantitative Limulus test, and fungal antigen and anti fungi antibody were examined at the same time.Results There were some minute differences in different mycosis groups, but the differences between mycosis groups and control group were all significant(P<0.05) ,and the sensitivity of serum (1→3)β D glucan measurement for early diagnosis of deep mycosis was higher than that of measuring fungal antigen and anti fungi antibody.Conclusion Serum (1→3)β D glucan measurement could be a practicable assay for early diagnosis of deep mycosis.