血清β_2-微球蛋白测定在消化系统疾病中的应用价值

The Value of Measurement of Serum β_2-Microglobulin in Diagnosis of Digestive Diseases

目的 探讨血清 β2 -微球蛋白 (β2 - Microglobulin,β2 - MG)在消化系统疾病中的变化水平和诊断价值。方法 采用放射免疫分析法检测 112例消化系统恶性肿瘤和 173例消化系统良性疾病患者和 6 0例正常人的血清 β2 - MG水平。结果 消化系统恶性肿瘤比消化系统良性疾病和正常人的血清 β2 - MG明显增高 (P<0 .0 1) ;高 β2 - MG血症发生率消化系统恶性肿瘤 (6 3.39% )较良性疾病 (16 .76 % )明显增高 (P<0 .0 1) ;血清β2 - MG增高在进展期肿瘤中占 92 .86 % ,相对稳定期肿瘤中仅占 5 3.5 7% (P<0 .0 1)。结论 血清β2 - MG有助于鉴别消化系统良、恶性疾病 ,而动态观察肿瘤患者的血清 β2 - MG变化对判断病程进展、评价预后有一定的临床实用价值。

Objective To explore the diagnostical value and change of serumβ 2 microglobulin in digestive diseases.Methods With radioimmunoassay,serumβ 2 microglobulins were measured in 112 patients with malignant digestive diseases and 173 patients with benign digestive disease and 60 healthy persons.Results Serumβ 2 microglobulin level was significantly higher in malignant digestive diseases than in benign digestive diseaseand healthy persons.(P<0.01).High serum β 2 microglobulin was seen more often in malignant digestive diseases than in benign digestive disease (63.39% vs 16.76%,P<0.01).High serum β 2 microglobulin was seen in 92.86% of patients with advanced stage and 53.57% of patients with relatively stable stage(P<0.01),respectively.Conclusion Measurement of serumβ 2 microglobulin should be helpful to differentiate the benign and malignant digestive diseases,and dynamic observation of serum β 2 microglobulin level could play and important role in assessing the development of diseases and prognosis.