芪丹通脉片对犬心肌耗氧量的影响

Effects of Qidantongmai tablet on myocardial oxygen consumption in dogs

目的 :探讨芪丹通脉片 (QDTMT)对犬心肌耗氧量的影响 .方法 :将实验犬随机分为空白对照组 (Control)、QDTMT大剂量组 (QDTMTH)、QDTMT小剂量组 (QDTMTL)及阳性对照组 (Diltiazem) .用血氧测定仪测定冠状动、静脉血氧含量 ,计算心肌耗氧量 ,氧利用率 .结果 :给药 6 0min后 ,QDTMTH动脉血氧含量降低 ,与Control相比有显著性差异 [(12 4 .2± 2 5 .4)vs (96 8± 4 0 ) ,(137.1± 15 .1)vs (99.9± 2 .4 )和 (137.4±12 .6 )vs (94 3± 2 8)g·L-1,P <0 .0 1].给药 4 5min后 ,QDTMTL心肌耗氧量显著低于Control [(74 .5± 14 )vs (94 .6±11.5 ) ,(76 .0± 17.3)vs(90 .6± 11.5 ) ,(76 .9± 10 .4 )vs (90 .6± 5 .5 )和 (74 .6± 16 .7)vs (95 .0± 4 .9)mL·min-1,P <0 .0 5 ].QDTMTH、QDTMTL的心肌氧利用率均下降 ;6 0min后 ,与Con trol相比有显著性差异 [(84 .9± 8.0 )vs (98.0± 6 .6 ) ,(84 .6±6 .3)vs (94 .6± 4 .3)和 (82 .4± 7.5 )vs (99.9± 6 .6 ) % ,P <0 .0 5 ].结论 :QDTMT可通过降低心肌耗氧量 ,降低氧利用率 ,改善心肌缺血 .

AIM: To study the effects of Qidantongmai tablet (QDTMT) on the amount of myocardial oxygen consumption in dogs. METHODS: Dogs were divided randomly into control, (QDTMT) high dosage (QDTMTH), low dosage (QDTMTL) and Diltiazem groups. The blood oxygen content of coronary arteries and veins was measured by hemoxmeter. Myocardial oxygen consumption and utility ratio of myocardial oxygen were calculated. RESULTS: In the QDTMTH group, the amount of oxygen in coronary arteries was reduced significantly from that of control group 60min after the administration of QDTMT [ (124.2±25.4 ) vs (968±40), (137.1±15.1) vs (99.9±2.4), (137.4±12.6) vs (943±28) g·L -1 , P <0.01]. Myocardial oxygen consumption was reduced significantly from that of the control 45 min after the administration of QDTMT. [(74.5±14) vs (94.6±11.5), (76.0±17.3) vs (90.6±11.5), (76.9±10.4) vs (90.6±5.5), (74.6±16.7) vs (95.0±4.9) mL·min -1 , P <0.05]. In QDTMTL group and QDTMH groups, the utility ratio of myocardial oxygen was reduced significantly from that of the control after 60 min the administration of QDTMT [(84.9±8.0) vs (98.0±6.6), (84.6±6.3) vs (94.6±4.3), (82.4±7.5) vs (99.9±6.6) %, P <0.05]. CONCLUSION: QDTMT can ameliorate myocardial ischemia by reducing the amount of myocardial oxygen consumption and the utility ratio of myocardial oxygen.