摘要
目的 :探讨冠状动脉病变程度与血C反应蛋白 (C -reactiveprotein ,CRP)和血尿酸 (Uridacid ,UA)的关系。方法 :测定 186例初诊为“冠心病、不稳定心绞痛”患者的血清CRP和UA水平 ,并根据冠状动脉造影的结果分组 ,观察血清CRP和UA与冠脉病变的关系 ,进行统计学分析。结果 :各组间血CRP水平 :冠脉正常组 (1.5 6± 1.3 2 )mg/mL ;冠脉轻度狭窄组 (2 .45± 1.87)mg/mL ;冠脉中度狭窄组 (3 .0 2± 2 .5 3 )mg/mL ;冠脉重度狭窄组 (4.2 8± 3 .15 )mg/mL ;冠脉完全闭塞组 (5 .3 6± 4.11)mg/mL。冠脉重度狭窄组和冠脉完全闭塞组与冠脉正常组比较。统计学处理差异有显著性意义 (P <0 .0 5 ) ,余组间比较差异无显著性意义 (P >0 .0 5 )。不稳定病变组CRP水平显著高于稳定病变组 (7.83± 4.66)mg/mLvs.(3 .3 8± 2 .2 7)mg/mL ,(P <0 .0 0 1)。各组间血UA值分别为 :冠脉正常组(2 81.7± 5 1.86) μmol/L ;冠脉轻度狭窄组 (3 0 9.2± 5 0 .11) μmol/L ;冠脉中度狭窄组 (3 3 4.6± 49.69) μmol/L ;冠脉重度狭窄组 (3 62 .7± 48.3 2 ) μmol/L ;冠脉完全闭塞组 (3 93 .4± 47.5 5 ) μmol/L。 5组间比较统计学处理差异均有显著性意义 (P <0 .0 5或P <0 .0 1)。不稳定病变组UA水平与稳定病变组相比 (3 42 .7± 5
Objective: To evaluate the relationships between the severity of coronary lesions withserum C-reactive protein (CRP) and urid acid.Methods: In 186 patients with primary diagnoses as coronary heart disease that were examined by selective coronary angiography, and in the mean time, the serum CRP and UAlevels were measured. These patients were grouped according to the results of coronary artery atherosclerosis stenosis.The relationships between the serum CRP and UAlevels with the severity of coronary lesions were assessed.Results: The serum CRP levels: coronary artery normal group(1.56±1.32)mg/mL;mild senosis group(2.45±1.87)mg/mL; middling stenosis group(3.02±2.53)mg/mL ;high-grade stenosis group(4.28±3.15)mg/mL; infarctiongroup(5.36±4.11)mg/mL. The high-grade stenosis group and the infarctiongroupcompare with the normal group, There were significant differences between them( P <0.05).and not differences betweenthe others( P >0.05). The serum CRP levels with unstable coronary lesionswere higher than stable coronary lesions(7.83±4.66)mg/mL vs.(3.38±2.27)mg/mL( P <0.001). The serum UAlevels: coronary artery normal group (281.7±51.86)μmol/L; mild senosis group(309.2±50.11)μmol/L; middling stenosis group(334.6±49.69)μmol/L;high-grade stenosis group(362.7±48.32)μmol/L;infarctiongroup(393.4±47.55)μmol/L,there were significant differences among them( P <0.05 or P <0.01). The serum UAlevels were not significant differences between the unstable coronary lesionsand the stable coronary lesions(342.7±54.68)μmol/Lvs.(337.5±46.32)μmol/L( P >0.05).Conclusion: The serum CRP levels were associated with the severity of coronary lesionsand significant positive related to the unstable coronary lesions. The serum UAlevels were significant positive related to the severity of coronary lesions and were notassociated with the unstable coronary lesions.Joining them up will be of great value to physicians in their diagnosis and treatment as well as prognosis.
基金
开封市科技攻关项目 (2 0 0 1)
