Ⅲ_A期非小细胞肺癌手术前后化疗比较

Comparison of pre-operative neoadjuvant and post-operative chemotherapy for non-small cell lung cancer in Ⅲ_A stage

目的 :通过病例对比 ,研究手术前新辅助化疗及手术后化疗对改善ⅢA 期非小细胞肺癌患者生存率的影响 .方法 :ⅢA 期非小细胞细胞肺癌患者 6 2例A组 (32例 )术前给予新辅助化疗 ,B组 (30例 )术后行辅助化疗 .结果 :中位生存时间A组 2 9mo ,B组 2 7mo .A组 1a生存率 81.2 % (2 6 / 32 ) ,2a生存率 4 6 .8% (15 / 32 ) ,3a生存率 37.5 % (12 / 32 ) ;B组分别为 83.3% (2 5 / 30 ) ,4 6 .6 % (14 / 30 )和 33.3% (10 / 30 ) .A、B组相应指标比较 ,均无显著性差异 (P >0 .0 5 ) .结论 :术前新辅助化疗并不能改善ⅢA 期非小细胞肺癌患者术后 1,2和

AIM: To study the effects of neoadjuvant therapy before operation and adjuvant chemotherapy after operation in cases of non small cell lung cancer in Ⅲ A stage. METHODS: 62 cases of non small cell lung cancer in Ⅲ A stage were divided into two groups at random: group A (32 cases) and group B (30 cases). Group A was given neoadjuvant therapy before operation and group B was given adjuvant chemotherapy after operation. RESULTS: The mean living time of group A was 29 months and that of group B was 27 months. The one year survival rate, two year survival rate and three year survival rate of group A were 81.2%(26/32),46.8%(15/32) and 37.5%(12/32)respectively. The one year survival rate, two year survival rate and three year survival rate of group B were 83.3%(25/30),46.6%(14/30) and 33.3%(10/30)respectively. The parameters between group A and group B had no significant difference ( P >0.05). CONCLUSION: Neoadjuvant therapy is not significantly related to the one year, two year or three year survival rate after operation.