吲达帕胺治疗老年单纯收缩期高血压疗效及其对代谢的影响

Effect of indapamide on the treatment isolatedsystolic hypertension in elderly patients

目的 :探讨吲达帕胺对老年单纯收缩期高血压 (ISH)的疗效及其对代谢的影响。方法 :10 2例老年ISH患者随机分为吲达帕胺治疗组 (n =5 2 ,吲达帕胺 1.2 5～ 2 .5mg/d)和非洛地平治疗组 (n =5 0 ,非洛地平 5～ 15mg/d)。每 1～ 2周测量坐位血压 1次。治疗前和治疗后 2个月后分别检测空腹血糖 ,血脂 ,血尿酸 ,血肌酐 ,血钾、钠和氯。结果 :两组治疗前后降压疗效差异均有非常显著性意义 (P <0 .0 1) ,但组间相比差异无显著性意义 (P 0 .0 5 )。两组治疗前后空腹血糖 ,血脂 ,血尿酸 ,血肌酐 ,血钾、钠和氯亦无统计学差异。结论 :吲达帕胺治疗老年ISH安全、有效 ,对空腹血糖 ,血脂 ,血尿酸 ,血肌酐 ,血钾、钠和氯无明显不良影响 。

Objective:To discuss the effects of indapamide on the treatment isolated systolic hypertension (ISH) in elderly patients.Methods:One hundred and two patients ISH of elderly were recuited and divided into group indapamide (n=52,indapamide 1.25 ～ 2.5 mg/d)and group felodipine(n=50,felopdipine 5～15 mg/d).Siting blood pressure was measured by the every 1～2 weeks.Fasting blood glucose, blood lipid,blood creatinine, uric acid, blood potassium,blood natrium and blood chlorine, were examined before and after 2 months treatment.Results:Comparing with before treatment, the blood pressure in both groups decreased significanthy, but not difference between 2 groups. The levels of blood glucose, blood lipids, creatinine and potassium didn't change after treatment.Conclusion:Indapamid is a safer drug for elderty patients with systolic hypertension.