雷贝拉唑钠治疗消化性溃疡的疗效观察

The curative effect of rabeprazole sodium in the treatment of peptic ulcer.

目的:观察新一代质子泵抑制剂雷贝拉唑对消化性溃疡的治疗效果。方法:30例消化性溃疡患者平均年龄(48.9±14.1)岁。雷贝拉唑用法为每日晨10 mg,观察指标为上腹痛、反酸和上腹烧灼感,每一次症状分别从严重程度和发作频率两方面进行评估,观察期为6天,分别于用药前、用药后第1天、第2天、第3天和第6天记录患者的症状变化。结果:用药后第1天三组症状严重程度积分值显著下降(上腹痛P<0.001,反酸0.002<P<0.005,上腹烧灼感P<0.001),发作频率显著减少(上腹痛P=0.048,反酸P=0.0004,上腹烧灼感P=0.0003)。第1、2、3、6天症状严重程度与用药前比较显著下降(P<0.01)。第6天疗效显著优于第1天。不良反应仅为干咳和皮肤瘙痒各1例。结论:雷贝拉唑用于治疗消化性溃疡,起效快,作用持久稳定,个体差异小。

Objetive: To evaluate the efficacy of the newprotonpump inhibitor rabeprazole in the treatment of peptic ulcer. Methods: 30 cases of peptic ulcer were enrolled and the mean age was 48.9 ±14.1 years.The dose was 10mg of rabeprazole once daily in the morning. The observation items included upper abdominal pain.regurgitation and heartburn. The symptom were evaluated from two sides of severity grade and paroxysmal frequency. The changes of sysmptoms were recorded before and after administration respectively during 6 days observation. Results: The scores of severity grade declined significantly on dayl of dosing(upper abdominal pain P<0.001, regurgitation 0.002<P<0.005, heartburn P<0.001), and the paroxysamal frequency also decreased remarkably (upper abdominal pain P = 0.048, regurgitation P =0.0004, heatburn P = 0.0003) . The grades dedined significantly on days 1, 2, 3 and 6 of dosing compared with the pretreatment. The efficacy of rabeprazol on the sixth day was better than that on the first day. The side effects were hack and dermal pruritus. Conclusion: Rabeprazole shows rapid onset, permanent and steady effect on peptic ulcer, and has little difference among people.