烧伤患者血清C-反应蛋白水平的观察

Postburn serum CRP level and its clinical significance

目的 :对比检测 C-反应蛋白 (CRP)与白细胞 (WBC)总数在判断烧伤病人病情的临床价值。方法 :将 6 0例烧伤病人按烧伤总面积大小分为二组 ,(大于 5 0 %组 ,n=30 ,小于 15 %组 ,n=30 ) ,于伤后 2 4小时 ,7天 ,14天采血 ,并与30例正常人对照分析。应用速率散射比浊法测定血清 CRP值 ,同时应用血球计数仪测定全血 WBC总数。结果 :两组病人在不同时期 CRP均高于正常 (P<0 .0 5 ) ;大面积烧伤组在不同时期 CRP值明显高于小面积烧伤组 (P<0 .0 5 ) ;两组烧伤病人白细胞总数在不同时期无显著性差异 (P>0 .0 5 ) ,且有 5 3.3%的病人 WBC在正常范围。结论 :CRP是判断炎症感染程度的良好指标 ,动态观测 CRP含量 ,尤其对烧伤病人等接受大量抗生素治疗的病人 ,其临床价值优于

Objective:To evaluate the clinical significance of monitoring C reactive protein and WBC in postburn patients Methods:Two group of postburn,one with total body surface area(TBSA)>50%(n=30) and one with TBSA<15%(n=30) were selected for the study.Blood samples collected in day 1,day 3 and day 7 were analyzed for C reactive protein (CRP) and WBC,using auto nephotechonology and auto hemocytometer respectively Results:Serum CRP concentration at all three stages increased significantly (P<0 05) in postburn patients,compared to normal reference range;CRP level in the extensive burn group increased significantly at all stages compared with the other group (P<0 05).WBC count showed no signified fluctuation at all stages and about 53 3% patients had a WBC level within normal reference rage Conclusion:Quantitative analysis and dynamic monitoring of CRP level has obvious clinical value in assessing postburn infection,especially for those patients who has received vast quantity of antibiotic that will suppress the blood WBC