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氯沙坦与依那普利联用对高血压左室肥厚逆转作用的探讨 被引量:3

Effects of Losartan combined with Enalapril on the reduction of left ventricular hypertrophy in patients with essential hypertension
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摘要 目的 :观察氯沙坦或依那普利单用或联用对老年原发性高血压左室肥厚 (L VH)的逆转作用。方法 :90例老年原发性高血压左室肥厚患者随机分成 3组 ,分别给予氯沙坦 5 0~ 10 0 mg/ d,依那普利 10~ 2 0 mg/ d,氯沙坦 2 5~ 5 0 m g/ d加依那普利 5~ 10 mg/ d治疗 6个月 ,观察左室肥厚的改善情况。结果 :氯沙坦组或依那普利组均能使左室质量指数较治疗前减低 (P <0 .0 5 ) ,而氯沙坦联用依那普利组减低左室质量指数的程度更大 (P <0 .0 1)。结论 :氯沙坦与依那普利均能逆转左心室肥厚 。 Objective:To evaluate the effects of Losartan of Enaprial alone and Losartan combined with Enalapril on the reduction of left ventricular hypertrophy (LVH) in essential hypertensive patients Methods:90 elderly hypertensive patients with left ventricular hypertrophy were randomized to receive Losartan (50~100mg/d),Enalaprial (10~20mg/d),and Losartan (25~50mg) combined with Enalaprial (5~10mg) respectively for six months.And the left ventricular thickness was measured befor and after treatment Results:The left ventricular mass index (LVMI) in the Losartan or Enalaprial group was reduced significantly after treatment (P<0 05).The LVMI of Losartan combined with Enalaprial group was reduced more significantly than that of the other groups (P<0 01) Conclusion:LVH was reduced by using Enalaprial or Losartan alone.The effect of combination of the two medicines was greater than that of the sigle medicine
机构地区 广西区江滨医院
出处 《广西医学》 CAS 2003年第4期513-515,共3页 Guangxi Medical Journal
关键词 药物联合治疗 氯沙坦 依那普利 高血压 左室肥厚 逆转作用 Hypertension Left ventricular hypertrophy Losartan Enalapril
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  • 1钱方毅.肾素—血管紧张素系统与高血压: 回顾与展望[J].中国循环杂志,1997,12(4):261-262. 被引量:27
  • 2[2]Menard J, Campbell DJ, Azizi M, et al. Synergistic effects of ACE inhibition and Ang Ⅱ antagonism on blood perssure, cardiac weight, and renin in spontaneously hypertensive rats. Circulation 1997; 96:3072
  • 3[3]Nunez E, Hosoya K, Susic D, et al. Enalapril and losartan reduced cardiac mass and improved coronary hemodynamics in SHR. Hypertension 1997; 29 (part 2):519
  • 4[4]Levy D, Garrison R J, Savage D, et al. Prognastic implications of echocardiographically determined left ventricular mass in the framingham heart study. N Engl J Med 1990; 312: 156

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  • 1何兆初,苏诚坚,孙明,黄帼英,潘洁贞.原发性高血压心血管重构的机制及氯沙坦的干预研究[J].岭南心血管病杂志,2000,6(4):231-233. 被引量:8
  • 2李晓东,孙亚清,马淑梅,孙照群.氯沙坦对高血压病人左室肥厚的影响[J].心血管康复医学杂志,1999,8(3):39-41. 被引量:14
  • 3方永辉,施志雄,苏迈,覃世坚.氯沙坦与卡托普利联用对高血压左室肥厚的逆转作用[J].广西医学,2005,27(9):1341-1343. 被引量:3
  • 4李春兰,董钰明,张振义.贝那普利联合氯沙坦对老年高血压脉压、心功能及左室肥厚的影响[J].兰州大学学报(医学版),2005,31(4):25-29. 被引量:10
  • 5Messerli FH, Ketelhut R. Left ventricular hypertrophy: a pressure-independent cardiovascular risk factor[J]. J Car- diovasc Pharmacol, 1993,22( Suppl 1 ) : 7.
  • 6Ke YS, Cao H, Yang T. Effect of combination of valsartan with benazepril on blood pressure and left ventricular hy- pertrophy in SHR[J]. Acta Pharmacol Sin, 2000,21 ( 11 ) : 1 043.
  • 7Avanza AC Jr, E1 Aouar LM, Mill JG. Reduction in left ventricular hypertrophy in hypertensive patients treated with enalapril, losartan or the combination of enalapril and losartan[J]. Arq Bras Cardiol, 2000,74(2 ) : 103.
  • 8Higgins JPT, Green S.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0[EB/OL].http :// www.coehrane-handbook.org.2011-03.2011-09-26.
  • 9Anan F, Takahashi N, Ooie T, et al. Effects of valsartan and perindopril combination therapy on left ventricular hypertrophy and aortic arterial stiffness in patients with es- sential hypertension[J]. Eur J Clin Pharmacol, 2005, 61 (5-6):353.
  • 10Brunner-La Rocca HP, Vaddadi G, Esler MD. Recent in- sight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin- II antagonism [J]. J Am Coil Cardiol. 1999.33(5) : 1 163.

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