摘要
目的 :观察氯沙坦或依那普利单用或联用对老年原发性高血压左室肥厚 (L VH)的逆转作用。方法 :90例老年原发性高血压左室肥厚患者随机分成 3组 ,分别给予氯沙坦 5 0~ 10 0 mg/ d,依那普利 10~ 2 0 mg/ d,氯沙坦 2 5~ 5 0 m g/ d加依那普利 5~ 10 mg/ d治疗 6个月 ,观察左室肥厚的改善情况。结果 :氯沙坦组或依那普利组均能使左室质量指数较治疗前减低 (P <0 .0 5 ) ,而氯沙坦联用依那普利组减低左室质量指数的程度更大 (P <0 .0 1)。结论 :氯沙坦与依那普利均能逆转左心室肥厚 。
Objective:To evaluate the effects of Losartan of Enaprial alone and Losartan combined with Enalapril on the reduction of left ventricular hypertrophy (LVH) in essential hypertensive patients Methods:90 elderly hypertensive patients with left ventricular hypertrophy were randomized to receive Losartan (50~100mg/d),Enalaprial (10~20mg/d),and Losartan (25~50mg) combined with Enalaprial (5~10mg) respectively for six months.And the left ventricular thickness was measured befor and after treatment Results:The left ventricular mass index (LVMI) in the Losartan or Enalaprial group was reduced significantly after treatment (P<0 05).The LVMI of Losartan combined with Enalaprial group was reduced more significantly than that of the other groups (P<0 01) Conclusion:LVH was reduced by using Enalaprial or Losartan alone.The effect of combination of the two medicines was greater than that of the sigle medicine
出处
《广西医学》
CAS
2003年第4期513-515,共3页
Guangxi Medical Journal