洛赛克与法莫替丁对照治疗90例上消化道出血的临床观察

Loseco compared with famotidine in the treatment of upper gastrointestinal bleeding:clinical analysis of 90 cases

目的 :用洛赛克与法莫替丁对比在临床治疗上消化道出血的效果。方法 :对 90例上消化道出血患者 ,运用随机抽样的方法 ,分为洛赛克治疗组和法莫替丁对照组各 4 5例 ,最初三天用静脉滴注 ,三天后改用口服 ,观察患者呕血及大便潜血情况。结果 :洛赛克治疗组 :显效率 :32 / 4 5 =71% ,有效率 :9/ 4 5 =2 0 % ,总有效率为 91% ;法莫替丁对照组 :显效率 :18/ 4 5 =4 0 % ,有效率 :13/ 4 5 =2 9% ,总有效率为 6 9%。两组总有效率比较经 χ2检验 ,有显著的差异性 (χ2 =5 .6 2 5 ,P<0 .0 5 )。结论 :本临床研究证明洛赛克对上消化道出血的止血疗效明显优于法莫替丁 。

Objective:To compare the therapeutic effect of Loseco and Famotidine in the treatment of upper gastrointestinal bleeding Methods:90 patients with upper gastrointestinal bleeding were randomly divided into two groups.Each group was 45 cases,they were treated with Loseco and Famotidine respectively.At the first three days taking via intravenous drip and then taking orally.The patients' haematemesis and stool occult blood were followed up at the same time Results:The significant effective rate,effective rate and total effective rate were 71%,20% and 91% respectively in Loseco treatment group and 40%,29% and 69% respectively in Famotidine controled group.There were significant difference in total effective rate between two groups (χ 2=5 625,P<0 05) Conclusion:The clinical study suggested that the hemostasis effect of Loseco in the treatment of upper gastrointestinal bleeding is significantly higher than that of Famotidine.The mechanism may be that the role of Loseco in inhibiting gastric acid secretion was much stronger than that of Famotidine