BN3C对大鼠心肌缺血再灌注损伤的保护作用

Protective Effect of BN3C on Myocardial Ischemia-reperfusion Injury in Rats

目的 :观察 4 - (3-硝基 -苯基 ) 1,4 -二氢 - 2 ,6 -二亚基 - 3,5 -吡啶二羧酸 3-甲基酯 ,5 - [2 - (1,6 -0 -失水 - 3,4 - 0 -异亚丙基 D-吡喃半乳糖 ) ]酯 (即 BN3C)对大鼠心肌缺血再灌注损伤的保护作用。方法 :结扎大鼠冠状动脉左前降支造成心肌缺血再灌注损伤。结果 :BN3C 2 .5μg/ kg、5μg/ kg、10μg/ kg可显著降低缺血再灌注后心律失常的发生率 ,缩短心律失常持续时间 ,防止室颤的发生 ;减少心肌丙二醛含量 ,提高心肌超氧化物歧化酶活性 ;降低血中肌酸激酶活性 ,缩小心肌梗死范围。结论 :BN3C对大鼠心肌缺血再灌注损伤有保护作用。

Objective: To study the effect of BN3C on myocardial ischemia reperfusion injury. Methods: The left coronary artery of the rat was ligated. Results: BN3C 2.5, 5 and 10 μg/kg was shown to decrease the incidence of arrhythmia induced by ischemia and reperfusion, shorten the duration of ventricular arrhythmia, eliminate the incidence of ventricular fibrillation; increase the activities of superoxide dismutase(SOD), decrease the malondiadehyde(MDA) contents; decrease the creatine kinase(CK) activities of serum, reduce the area of myocardial necrosis.