幽门螺杆菌感染与小儿复发性腹痛的相关性研究

Relationship between heiicobacterium pyloric infection and recurrent abdominal pain in children

目的研究幽门螺杆菌感染与小儿复发性腹痛的相关性。方法采用^(13-)C尿素呼气试验(^(13-)C-UBT)检测60例健康儿童和187例复发性腹痛(RAP)儿童的幽门螺杆菌感染率,观察幽门螺杆菌根除后RAP患儿的腹痛缓解率,并对RAP儿童在性别、年龄、病程、腹痛方式等方面进行比较.结果 RAP儿童和对照组的幽门螺杆菌感染的阳性率分别为31.4％、15％,两组比较有显著差异(p<0.05),幽门螺杆菌阳性的RAP儿童进行抗幽门螺杆菌治疗后,幽门螺杆菌已根除和未根除的腹痛缓解率分别为78.5％、37.5％,两组比较有显著差异(p<0.05)。在3～5岁、6～9岁、9～12岁3个年龄组的幽门螺杆菌感染率分别为42％、32％、32％,三组比较无显著差异(p>0.05).幽门螺杆菌感染与RAP儿童的性别、平均年龄、病程及腹痛方式之间进行比较,亦无显著差异(p>0.05)。结论幽门螺杆菌感染与复发性腹痛有密切的相关性,可能为复发性腹痛的主要致病因素,根除幽门螺杆菌治疗可缓解复发性腹痛儿童的腹痛症状,幽门螺杆菌感染与复发性腹痛儿童的性别、病程及腹痛方式无关.

Objective To investigate the relationship between helicobacterium pyloric(Hp) infection and recurrent abdominal pain(RAP) in children. Methods ^(13)C urea breathing test(^(13)C-UBT) was undertaken in 187 children with RAP and 40 normal children. Results The positive rate of Hp infection was 31.4% in RAP children and 15% in normal children. There was significant difference between tow groups(p<0.05). After eradication treatment in RAP children with Hp infection, symptoms were disappeared in 78.5% of children whose H. pylori infection was eradicated compared with 37.5% of those in whom the infection was not eradicated (p<0.05). The rate of Hp infection in 3-6 old, 6-9 old and 9-12 old RAP children was 42%, 32% and 32% respectively(p>0.05). And There was not significant difference between helicobacterium pyloric infection and sex, duration and the form of abdominal pain(p>0.05). Conclusion There was a high correlation with Hp infection and RAP in children. Hp infection may be one of the major causes of RAP. And abdominal pain may be released after eradication of Hp.