摘要
目的 观察脑细胞生长肽 (CCGP)对庆大霉素 (GM )引起的耳蜗内琥珀酸脱氢酶 (SDH)的影响。方法 分别用脑干听觉诱发电位 (BAEP)和组织化学方法检测动物听阈的变化和耳蜗毛细胞线粒体内SDH活性变化。结果 CCGP能降低GM引起的BAEP反应阈的上升幅度和耳蜗毛细胞SDH活性 ;CCGP能保护耳蜗毛细胞SDH的活性 ,减轻了毛细胞的损伤。结论 CCGP能保护SDH的活性。保护耳蜗毛细胞SDH的活性 ,维持毛细胞的能量代谢 ,减轻毛细胞的损伤 。
Objective: To investigate the preventive effects of cerebrocellular growth peptide(CCGP) on the inner ear damage induced by gentamyein (GM) in guinea pigs, and clarify its mechanism. Methods: The hypoacusis severity and enzymetic activity in the cochlear hair cells were examined by brainstem auditory evoked potential (BAEP) and histochemistry respectively. Results: CCGP reduced the elevated BAEP reaction thresholds. It protected the activities of mitochondrial succinate dehydrogenase in the cochlear hair cells. Conclusion: CCGP can reduce GM ototoxicity. The mechanism of CCGP effect may be associated with protecting the activity of mitochondrial enzyme.
出处
《泰山医学院学报》
CAS
2002年第4期324-326,共3页
Journal of Taishan Medical College
基金
山东自然科学基金 (Y95C2 0 42 )
广州市科委科学基金资助 (Z18- 0 3- 2 9)
关键词
脑细胞生长肽
耳蜗
琥珀酸脱氢酶
影响
庆大霉素
cerebrocellular growth peptide
cochlea
ototoxicity
succinate dehydrogenase
