240例肝硬化患者血清病毒标志物分析

Analysis of virus indication in the serum of 240 patients with livercirrhosis

目的 探讨肝硬化患者血清病毒的感染模式及临床意义。方法 采用ELISA法检测甲—庚型肝炎病毒抗原或抗体 ,PCR法检测HBVDNA ,HCVRNA。结果 2 40例肝硬化血清病毒的感染率依次为 :HBV >HCV >HDV >HGV >HEV >HAV。HBVDNA阳性率为 61 2 5 % ,HCVRNA阳性率为 15 2 2 %。结论 肝硬化以HBV的感染的“小三阳”为主要模式 ,以HBV ,HCV ,和 /或HDV ,HGV ,HEV双重及多重感染为多见 ,病毒核酸 (HBVD NA ,HCVRNA)

Objectiv: To investigate the infection mode of virus in the serum of patients with livercirrhosis. Methods: ELISA method was used to examine antigens or antibodies of hepatitis virus and PCR was used to detect HBVDNA and HCVRNA in serum. Results: In 240 patients with livercirrhosis, HBVDNA was 61.25%, HCVRNA 15.22%, and the percentages of HBV, HCV, HDV, HGV, HEV and HAV decreased in order. Conclusion: Most of the cases of livercirrhosis are correlated with HBV infection and a lot of them with HBV/HCV or HBV/HCV/HDV/HGV/HEV infection. Virus nucleic acid such as HBVDNA, HCVRNA is the direct evidence that the infectiousness of livercirrhosis can be estimated.