血清唾液酸检测在妇科肿瘤鉴别诊断中的意义

Serum sialic acid detection in differential diagnosis of gynecologic tumors

目的 探索血清唾液酸对妇科常见肿瘤良性与恶性鉴别诊断的价值。方法 采用化学比色法对 44 0例妇科肿瘤患者进行血清唾液酸含量测定 ,其中子宫肌瘤 10 7例 ;卵巢良性囊腺瘤 2 17例 ;卵巢成熟畸胎瘤 2 8例 ;卵巢癌 88例。结果卵巢癌组患者血清唾液酸 ( 72 6 85± 13 5 2 6) ,子宫肌瘤组 ( 5 73 0 8± 68 60 ) ,卵巢良性囊腺瘤组( 5 5 7 2 5± 63 3 9) ,卵巢成熟畸胎瘤组 ( 5 69 11± 5 9 71) ,四组相比卵巢癌组高于其他三组且有统计学意义 (P <0 0 0 1)。而三个良性肿瘤组之间比较均无统计学意义 (P >0 0 5 )。且卵巢癌患者阳性率均显著高于其他三组阳性率 (P <0 0 0 0 1)。经诊断试验的真实性评价 ,血清唾液酸检测对恶性肿瘤的诊断真实性较高。

Objective: To explore the value of sialic acid in thedifferential diagnosis of common gynecologic benign tumors and malignant tumors. Methods: The content of serum sialic acid was detected by spectrophot meteral method in 440 patients with gynecologic tumors: 107 with leiomyoma of uterus, 217 with ovarian benign cystadenoma, 28 with mature malignant teratoma, and 88 with ovarian carcimoma. Results: The serum sialic acid content in ovarian carcimoma group was 726.85±135.26;leiomyoma of uterus,573.08±68.60; ovarian benign cystadenoma, 557.25±63.39; and ovarian mature teratoma,569.11±59.71. Among the four groups, the serum siali acid content of ovarian carcinoma group was the highest (P<0.001), and statistically significant while the results of the other three groups were not (P>0.005). The positive rate in ovarian carcinoma was obviously higher than that in the rest. (P< 0.001). Conclusion: Serum sialic acid content detection is clinically of great value in the differential diagnosis of gynecologic tumors.