感染性休克患者血清肿瘤坏死因子-α的测定及临床意义

Significance of plasma tumor necrosis factor-α(TNF-α)level in septic shock

目的 :研究感染性休克患者血清肿瘤坏死因子 -α(TNF -α)的水平及其临床意义。方法 :采用ELISA法检测感染性休克患者血清TNF -α的含量。结果 :35例感染性休克患者血清TNF -α的含量均高于正常对照组 (P<0.01) ,并随病情加重而增高。结论 :TNF -α参与了感染性休克的发病过程 ,测定其含量 ,有助于临床评估病情及判断预后。

Objective:To investigate the significance of plasma tumor necrosis factor-α(TNF-α)level in septic shock.Methods:ELISA methods were used to determine the TNF-αlevel in septic shock.Results:Plasma TNF-αlevels in the patients with septic shock were significantly higher than the levels in healthy subjects(P<0.01),and high TNF-αlevels were found in nonsurvivors compared to survivors.Conclusion:TNF-αplays important role in sepˉtic shock.The assay of them may be helpful for evaluation of septic shock and prognosis.