白细胞介素18在结肠腺癌及腺瘤中的作用探讨

Interleukin 18 Expression in Colon Cancer and Adenoma

目的 了解白细胞介素 18(IL - 18)在结肠腺癌及腺瘤中的表达及其作用。方法 采用免疫组化方法检测 IL - 18在 2 1例结肠腺瘤及 33例结肠癌中的表达。结果 结肠腺癌、腺瘤及非癌非瘤粘膜上皮 IL - 18表达的阳性率分别为 78.8% ,10 0 % ,10 0 % ,无显著性差异 (P>0 .0 5 )。无表达主要集中在中、低分化腺癌 ,腺癌分化程度越高 ,IL - 18表达越强 (P<0 .0 5 )。结肠腺瘤阳性率与伴随的不典型增生程度无明显相关 (P>0 .0 5 )。结论 IL - 18在结肠腺瘤中表达仍较丰富 ,但结肠癌中表达减少或不表达 ,分化越低 。

Objective To investigate the expression of interleukin 18 in mucosa of colon cancer and adenoma. Methods Expression of interleukin 18 was measured with immunohistochemical staining. Results The expression rates of IL 18 in colon cancer, adenoma and relative normal mucosa were 78.8%,100% and 100%, respectively ( P >0.05). In the case of colon cancer, the higher the cancer was differentiated, the higher the IL 18 expression level was observed ( P <0.05). In the case of colon adenoma, no significant relation was noted between the grade of dysplasia and the expression of IL 18 ( P >0.05). Conclusion In colon adenoma, all mucosae express IL 18. But in colon cancer, IL 18 expression is decreased or absent, and the lower the cancer is differentiated, the lower will be the level of IL 18 expression in epithelium.