肝硬化患者血清瘦素水平测定及其临床意义的探讨

Measuring the level of serum leptin in cirrhosis and dinkal significance.

为了解肝硬化患者血清、腹水中瘦素水平情况,探讨其可能的临床意义。选择肝硬化组、对照组各21例,分别测定受试者的血脂、肝功、血糖、胰岛素、血清瘦素及部分腹水瘦素水平,测量其身高、体重,计算体重指数、体脂肪含量。瘦素、胰岛素分别采酶联免疫吸附试验、放射性免疫试验方法测定,胰岛素抵抗用HOMA模式估算。结果显示:肝硬化、对照组的血清瘦素水平差异不显著,且肝硬化组无性别差异。肝硬化患者的血清瘦素水平与体重指数(BMI)、总蛋白、总胆固醇、空腹胰岛素相关,与胰岛素抵抗(IR)无关。腹水中的瘦素水平与腹水的性质有关,渗出液高于漏出液。上述结果说明肝硬化患者血清瘦素水平表现异常,与疾病本身相关。

To determine the possible clinical significance If the serum leptin through estimating its levels in cirrhosis. 21 patients with cirrhosis of liver and 21 normal persons were admitted to the investigations: The blood glucose, liver function, blood grease, insulin, lepatin from serum and partial ascites, the candidates height and weight were measured respectively. Simultaneously, body mass index and percent of body fat was calculated. The level of leptin was measured by ELISA, Insulin resistance was showed by HOMA. The result showed that there was no significant difference between the level of leptin of the cirrhosis and the controls. Moreover, the serum leptin is irrelevant to the gender in the cirrhosis group, the serum leptin in cirrhosis is relevant to BMI. TP. TC. INS. and has no relationship with insulin resistance. The level of leptin in ascites is closely related to the quality of ascite, ie, the level of leptin in exudate is higher than in transudate. This suggested that the serum leptin was abnormal and correlated with the disease itself.