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肺压宁胶囊治疗慢性阻塞性肺病73例疗效观察 被引量:10

Observing the therapeutical effects of capsule Feiyaning on 73 patients with chronic obstruction pulmonary disease (COPD)
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摘要  目的:观察纯中药复方制剂———肺压宁胶囊(CapFYN)对慢性阻塞性肺病(COPD)的长期疗效。方法:选取确诊的COPD患者73例,分为治疗组42例,对照组31例。两组基础治疗相同(均不使用氨茶碱),治疗组用肺压宁胶囊每次4粒,每天3次;对照组用硝苯吡定片剂10mg每天3次,对比观察治疗20周前后患者的咳嗽、咳痰、神疲、乏力等症状,舌腹静脉瘀血征,肺功能(1s用力呼气容积/用力肺活量即FEV1/FVC)以及平均肺动脉压的组内和组间变化,并计算它们的危险度(Risk)、相对危险度(RR)、相对危险度减少(RRR)和绝对危险度减少(ARR)值,以评价治疗效果。结果:随访率分别为98%和99%;神疲、乏力症状、瘀血征、肺功能、肺高压4项结果的RR值均>1,症状的RRR为-0 476,余3项的RRR值均<-0 5,4项的ARR值依次为26 11%、43 80%、24 29%、22 39%;两组患者肝肾功能及血、尿常规均无明确改变。结论:肺压宁胶囊是一种长期服用方便、安全,能改善病人症状、瘀血征和气道气流阻塞及降低肺动脉高压的纯中药复方制剂,可作为COPD患者综合治疗的一种辅助方药。 Aim: The therapeutical effects of Cap. Feiyaning were observed on the chronic obstruction disease (COPD) in comparison with Nifedipin. The Cap. Feiyaning is the Yiqi Huoxue compound prescription of pure traditional Chinese medical herbs.Methods: COPD 73 patients were divided into Feiyaning treatment group and Nifedipin control group ,the former , 42 patients were treated with Cap. Feiyaning 4 # tid, the later, 31 patients were treated with Nifedipin 10 mg tid ,the basic treatment of both groups were same and no using aminophyllin. The treatment period of both groups were 20 weeks, these changes before and after treatment were comparatively observed: contained symptoms (cough, expectoration, short of breath and so on), Yuxue physical sign (stasis sign of the tongue abdominal vein ), pulmonary function (FEV 1/FVC) and MPAP, of which the values of Risk? Relative risk(RR)? Relative risk reduction(RRR) and absolute risk reduction(ARR) were calculated respectively so as to evaluate the therapeutical effects of Cap. FeiYaning.Results: The rate of follow up were 98% and 99% respectively; the values of RR all surpassed 1, the RRR of the symptoms was equal to -0 476 and that of the physical sign, pulmonary function and pulmonary hypertension were all smaller than -0 5, the ARR was respectively equal to 0 261 1 , 0 438 0 , 0 242 9 and 0 223 9 , which showed the Cap. Feiyaning was possessed of better therapeutical effects; in the mean time of treatment the functions of liver and kidney and the routine examination of blood and urine have no significant change. Conclusion:Cap. Feiyaning was a conveniently taken, safe and efficient supplement drug for long period treatment of COPD.
出处 《暨南大学学报(自然科学与医学版)》 CAS CSCD 2002年第6期40-43,共4页 Journal of Jinan University(Natural Science & Medicine Edition)
基金 广东省中医药管理局基金项目(96-04365)
关键词 益气活血 肺压宁胶囊 疗效 慢性阻塞性肺病 缺氧性肺动脉高压 Yiqi Huoxue Cap. Feiyaning therapeutical effect chronic obstruction pulmonary disease hypoxic pulmonary hypertension.
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