Th1细胞因子水平与鼻咽癌患者预后的相关性分析

Correlation between the Level of Auxiliary T cells(Th1) and Prognosis of Patients with Nasopharyngeal Carcinoma and the Prognostic Risk Factors Analysis

目的探讨辅助性T细胞Th1细胞因子与鼻咽癌患者预后的相关性。方法选取我院收治的鼻咽癌患者150例,对患者进行随访,分析治疗前患者的Th1细胞因子水平与预后的相关性及不良反应发生率;采用单因素、多因素回归分析对影响患者预后的危险因素进行深入探讨。结果患者的不良反应总发生率为9.3%;1年生存率为86.7%,3年生存率为68.7%,5年生存率为58.7%;生存时间与白细胞介素(IL-2)水平呈正相关,与肿瘤坏死因子(TNF-α)水平呈负相关(P<0.05),与干扰素(IFN-γ)水平无相关性(P>0.05);生存率与临床分期、T分期、N分期密切相关(P<0.05);影响患者预后的危险因素包括TNM分期、年龄、肿瘤体积以及治疗方案等(P<0.05)。结论 Th1细胞因子中的TNF-α、IL-2可作为预测鼻咽癌患者预后的重要指标,且分期越高、年龄越大,患者的预后越差。

Objective To explore the correlation of auxiliary T cell(Th1)level with the prognosis of nasopharyngeal carcinoma patients and to analyze the prognostic risk factors.Methods A total of 150 patients with nasopharyngeal carcinoma in our hospital were followed up.The relationship between their Th1 cytokine levels before treatment and their prognosis was analyzed.The risk factors on prognosis were further investigated by single factor and multiple factors regression analysis.Results After treatment,the incidence of adverse reactions of the patients was 9.3%.The 1-year survival rate was 86.7%,and the 3-year survival rate was 68.7%.The survival time was positively correlated with the level of interleukin(IL-2),but negatively correlated with the level of tumor necrosis factor(TNF-α)(P<0.05).There was no correlation between the survival time and the interferon(IFN-γ)level(P>0.05).At the same time,the survival rate had a close relationship with the N stage,clinical stage and T stage of patients(P<0.05).The risk factors affecting the prognosis of patients included TNM stage,age,tumor volume and therapies(P<0.05).Conclusion Auxiliary T cytokines TNF-αand IL-2 could be taken as important prognostic indicators for nasopharyngeal carcinoma patients.The higher the stage and the older the patients,the worse the prognosis.