脾多肽辅助同步放化疗对局部晚期非小细胞肺癌患者免疫功能的影响

Effects of Lienal Polypeptide-assisted Chemoradiotherapy on Immune Function of Patients with Locally Advanced Non-small Cell Lung Cancer

目的探讨脾多肽辅助同步放化疗对局部晚期非小细胞肺癌患者T淋巴细胞亚群及NK细胞的影响。方法选取我院就诊的114例局部晚期非小细胞肺癌患者,采用随机数表均分为观察组和对照组。对照组接受同步放化疗治疗,观察组接受脾多肽辅助同步放化疗治疗。比较两组患者治疗前及治疗30 d后T淋巴细胞亚群及NK细胞水平;比较两组患者治疗前后全身状况、不良反应发生率及治疗效果。结果治疗后观察组有效率明显高于对照组(P<0.05),控制率与对照组无明显差异(P>0.05);观察组术后不良反应发生率明显低于对照组(P<0.05);治疗前两组患者全身状况KPS评分无明显差异,治疗后两组患者KPS评分均明显高于治疗前(P<0.05),且观察组KPS评分提高率明显高于对照组(P<0.05);两组患者治疗前T淋巴细胞亚群及NK细胞水平无明显差异,治疗30 d后两组患者T淋巴细胞亚群及NK细胞水平均明显下降,但观察组CD3^+、CD4^+及NK细胞水平明显高于对照组(P<0.05),CD8^+水平显著低于对照组(P<0.05)。结论脾多肽辅助同步放化疗可改善局部晚期非小细胞肺癌患者的免疫功能,较单一同步放化疗的疗效更好,安全性更高。

Objective To investigate the effects of lienal polypeptide injection as adjuvant concurrent with chemoradiotherapy on T lymphocyte subsets and NK cells in patients with locally advanced non-small cell lung cancer.Methods A total of 114 patients with locally advanced non-small cell lung cancer were divided into observation group and control group.The control group received concurrent chemoradiotherapy,while the observation group received lienal polypeptide injection and concurrent chemoradiotherapy.The general condition and therapeutic effect of the two groups were compared before and after treatment.The adverse reactions of the two groups were analyzed statistically.The percentage of T lymphocyte subsets and NK cells in peripheral blood lymphocyte was compared between the two groups.Results After treatment,the effective rate of the observation group was significantly higher than that of the control group(P<0.05).As for the control rate,no difference was found between the two groups(P>0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Before treatment,there was no significant difference in the KPS scores of the whole body condition between the two groups.After treatment,the KPS scores of both groups were higher than before treatment(P<0.05),and the KPS score of observation group was significantly higher than that of control group(P<0.05).The percentage of T lymphocyte subsets and NK cells in peripheral blood lymphocyte increased significantly.The percentage of CD3+,CD4+and NK cells in peripheral blood lymphocyte in the observation group was significantly higher than that in the control group(P<0.05).Conclusion The lienal polypeptide-assisted concurrent chemoradiotherapy could improve the immune function of patients with locally advanced non-small cell lung cancer.