榄香烯注射液辅助放疗对肺癌合并脑转移患者的疗效

Efficacy of Elemene Injection Adjuvant Radiotherapy for Lung Cancer Patients with Brain Metastases

目的探讨放疗治疗肺癌合并脑转移患者过程中应用榄香烯注射液辅助治疗的疗效。方法选取我院收治的肺癌合并脑转移患者144例,随机分为两组,对照组进行放疗,观察组进行榄香烯注射液辅助放疗。比较两组患者的临床疗效、血清基质金属蛋白酶-2(MMP-2)、MMP-9水平以及治疗后1～3周白细胞数量变化。结果治疗后观察组临床疗效显著优于对照组,差异具有统计学意义(P<0.05)。治疗前两组患者血清MMP-2、MMP-9水平比较,差异无统计学意义(P>0.05),治疗后两组患者血清MMP-2、MMP-9水平均下降,且观察组显著低于对照组,差异有统计学意义(P<0.05)。治疗后1～3周,两组患者白细胞数量均升高,且观察组明显高于对照组,差异有统计学意义(P<0.05)。结论榄香烯注射液辅助放疗对肺癌合并脑转移患者的治疗效果较满意,可在临床上广泛应用。

Objective To investigate the efficacy of elemene injection in the treatment of patients with severe lung cancer complicated with brain metastases.Methods A total of 144 patients with severe lung cancer complicated with brain metastases were enrolled in our hospital.The patients were randomly divided into two groups.The control group received radiotherapy.The observation group received elemene injection adjuvant chemotherapy.The clinical efficacy,serum levels of matrix metalloproteinase-2(MMP-2)and MMP-9,and the changes in white blood cell counts from 1 to 3 weeks after treatment were compared between the two groups.Results After treatment,the curative effect was improved in both groups.The clinical effect of the observation group was significantly better than that of the control group(P<0.05).Before treatment,there was no significant difference in serum MMP-2 and MMP-9 levels between the two groups(P>0.05).After treatment,the levels of serum MMP-2 and MMP-9 in the two groups were decreased.The level of inflammatory factors in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).The number of white blood cells increased in both groups in 1~3 weeks,and it was even significantly more in the study group than in the control group in 1~3 weeks(P<0.05).Conclusion In the course of radiotherapy for patients with severe lung cancer and brain metastases,the adjuvant treatment of elemene injection showed a satisfactory curative effect and could be widely used in clinical practice.