预防性治疗重症胰腺炎合并肺损伤的体会

Effect of Preventive Therapy on Acute Lung Injury Induced by Severe Acute Pancreatitis

目的:探讨预防性治疗重症急性胰腺炎(sAP)合并肺损伤对患者预后的影响。方法:将我院1996年2月～2001年12月收治的64例SAP患者分为两组:常规治疗组33例,预防治疗组31例。结果:常规治疗组肺损伤发病率48.5%(16/33),ARDS发病率30.3%(10/33);预防治疗组肺损伤发病率35.5%(11/31),ARDS发病率9.7%(3/31)。结论:采用乌司他丁联合大剂量地塞米松及低分子右旋糖酐预防性治疗SAP合并肺损伤,可有效降低并发症,提高SAP的治愈率。

Purpose: To study effect of preventive therapy on acute lung injury induced by severe acute pancreatitis(SAP). Methods: From February 1996 through December 2001 ,64 patients with SAP were divided into routine treated group( n =33) and preventive treated group( n =31). Results: The incidences of lung injury were 48.5% ( 16/33) and ARDS were 30% (10/30) in routine treated group respectively, while there were 35. 5% (11/33) and 9. 7% (3/31) in preventive treated group respectively. Conclusion: UTI combined with large doses dexamethason and dextrane -40 can preventively treat acule lung injury induced by SAP, effectively decrease complication of SAP, increase curing rate of SAP.