老年胶质母细胞瘤的治疗进展

Advances in the treatment of glioblastoma in older adults

胶质母细胞瘤是成人最常见的原发性颅内恶性肿瘤,发病率呈逐年上升趋势,其中超过半数的新诊断胶质母细胞瘤患者年龄超过65岁。目前,胶质母细胞瘤的标准治疗方案为手术切除序贯同步放化疗,由于老年胶质母细胞瘤患者存在个体差异和肿瘤异质性,对于老年胶质母细胞瘤的最佳治疗方案仍存在争议。本文旨在结合老年胶质母细胞瘤患者的特点对治疗策略(包括外科手术治疗、放化疗及免疫治疗等)作一综述,以期为老年胶质母细胞瘤患者制定合理的治疗方案提供参考。

Glioblastoma is the most common primary malignant brain tumor in adults. More than half of newly diagnosed glioblastoma patients are over 65 years old. The current standard treatment for glioblastoma is surgical resection, followed by concurrent chemoradiotherapy. There is no consensus recommendation regarding the best available treatment for glioblastoma in elderly patients due to the individual specificity and tumor heterogeneity. This review discussed the management of glioblastoma in elderly patients including surgery, chemoradiotherapy, and immunotherapy, in order to provide a reference for the development of a reasonable treatment regimen for elderly patients with glioblastoma.