老年抑郁症病因及发病机制研究新进展

Advances in the etiology and pathogenesis of senile depression

老年抑郁症是一种复杂的精神性疾病,其影响因素可有负性生活事件、年龄、性别、躯体疾病、经济状况、个人脆弱性、社会支持等,而这些因素构成的大脑背景更容易受到压力的影响,从而导致生理结构的病理改变,例如脑结构改变、血管损伤、炎症机制、神经内分泌改变等。本文旨在对老年抑郁症的病因及发病机制的研究新进展进行综述,以期为临床治疗和预防老年抑郁症提供参考。

Depression in the elderly is a complex mental disease. The influencing factors includes negative life events, age, gender, physical illness, economic status, personal vulnerability, social support, etc. The brain background constituted by these factors is more susceptible to the influence of stress, leading to pathological changes in the physiological structure, such as brain structural changes, vascular injury, inflammatory mechanisms, neuroendocrine changes, etc. This peper aims to review the recent advances in the etiology and pathogenesis of senile depression in order to provide reference for clinical treatment and prevention of depression in the elderly.