摘要
急性肺损伤(acute lung injury,ALI)/急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)是各种内外致病因素导致的以弥漫性肺部浸润、内皮损伤及肺泡毛细血管渗透性增加为主要特征的急性呼吸衰竭综合征。近年来研究表明,血管紧张素II(angiotensin II,Ang II)与ALI存在密切的联系。Ang II是肾素-血管紧张素系统(RAS)中的主要效应分子,Ang II可通过上调多种炎性因子的表达,促进肺水肿、肺实质细胞凋亡、炎症反应及肺纤维化,与ALI发生、发展及预后关系密切。在此就Ang II及其受体信号通路在ALI中的作用予以概述。
Acute lung injury(ALI) or acute respiratory failure, a clinical syndrome of rapid-onset lung failure, is characterized by leukocyte recruitment and injuries to the endothelium which increase the permeability of alveolar capillaries. Recently, studies showed that angiotensin Ⅱ(Ang Ⅱ) is closely related to ALI. As the major factor of renin-angiotensin(RAS) system, Ang Ⅱ promotes pulmonary edema, apoptosis,inflammatory responses and pulmonary fibrosis by upregulating inflammatory factors. Therefore, Ang Ⅱ is associated with progression, development and prognosis of ALI. Here we summarized a review of the roles of Ang Ⅱ and its related signaling pathways in ALI.
出处
《临床检验杂志（电子版）》
2015年第2期850-858,共9页
Clinical Laboratory Journal(Electronic Edition)
