C反应蛋白的研究进展及临床应用

The research progress and clinical application of C-reactive protein

C-反应蛋白(C-reaction protein,CRP)自1930年被发现以来,其分子结构,理化特征,生理特性,检测方法及临床意义等方面受到了学者的广泛研究与探讨,经历了一系列的发展革新。进入21世纪以来,伴随分子生物学和免疫学的发展,CRP测定方法发展迅速,目前可用新的敏感方法检测出更低浓度的CRP,即超敏C-反应蛋白(hypersensitive C-reaction protein,hs-CRP),在临床应用方面也越来越广泛。本文就CRP的生物学特性、检测方法的沿袭及其在临床应用中的最新进展等方面作一综述。

C-reactive protein(CRP) has been found since 1930 s and widely studied and explored in the aspects of its molecular structure,physical properties,physiological characteristics,detection methods and clinical significance.Since entering twenty-first Century,along with the development of molecular biology and immunology,CRP determination method has developed rapidly.At present,it can be used to detect lower concentrations of CRP,i.e hypersensitive C-reaction protein(hs-CRP),which is becoming more and more widely used in clinical application.In this paper,the biological characteristics of CRP,the detection methods and the latest progress in clinical applications are reviewed.