PCT在不同病原体感染诊断中的研究进展

The research progress of PCT in the diagnosis of different pathogens

随着科研和分析诊断技术的不断进步,很多反映病原体感染或某种疾病状态的实验室指标得以应用到临床诊断实践中。降钙素原是一个较新的指标,是近年发现的用于细菌感染诊断和鉴别诊断的新的血清学标志物,研究发现PCT不仅可用于全身细菌感染诊断和鉴别诊断,对疗效观察,预后判断也具有很高的临床价值,还可以反映疾病的严重程度及炎症活动情况,与传统的炎症反应指标相比具有更高的特异性和敏感性。此外,全身性真菌感染或病毒感染后血清PCT的含量也会升高,但其变化的幅度和程度跟细菌感染所引起的PCT含量变化不同。因此,PCT不仅可以用于诊断细菌感染性疾病,而且可用于真菌、病毒以及支原体等非典型病原体感染的诊断。本文就PCT在不同病原体感染后含量变化予以综述。

With the development of scientific research and analysis,many laboratory indexes reflecting the status of pathogen infection and some diseases can be applied to clinical practice.PCT is a new marker for diagnosis.It is found that PCT can be used for diagnosis and differential diagnosis of systemic bacterial infection.The clinical value can also reflect the severity and inflammatory activity of the disease.In addition,the levels of PCT in serum after fungus,viral or mycoplasma infection can also increase,but these changes of PCT level are different from bacterial infection.Therefore,PCT can be used in the diagnosis of bacterial infection and differentiate the diagnosis of atypical pathogens such as fungi,viruses and mycoplasma.In this paper,the changes of PCT in different pathogen-infectious serum were summarized.