血清胱抑素C水平与肾功能正常的冠心病患者发病及血管病变严重程度相关性分析

The Association between Serum Cystatin C Levels and Coronary Artery Disease and Its Severity in Patients with Normal Renal Function

目的:评估血清胱抑素C(CysC)水平与无明显肾脏疾病的冠心病(CAD)患者的严重程度和冠状动脉病变程度之间的相关性。方法:连续入选于我院的485例无肾功能不全且疑似CAD行冠脉造影的患者。根据受试者基线血清CysC水平四分位数分为4组。分析CysC与冠心病Gensini评分和冠脉病变数量的相关关系。结果:CAD患者血清中CysC水平高于非CAD患者(P<0.05)。而且CysC水平随着冠状血管的累及病变数和Gensini评分而升高(P<0.05)。多因素logistic回归分析显示CysC与CAD的存在独立相关(OR=2.673,P<0.05)。结论:血清CysC水平升高与肾功能正常的患者CAD的存在和严重程度显着相关。

Objectives:This study aim to evaluate the role of cystatin C in determining the presence and the severi-ty of patients withcoronary artery disease(CAD)with normal renal function.Methods:A total of 485 patients without abnormal renal function were included in this study. Patients were divided into four groups according to cystatin C quartile.The study analyzed the relationship of cystatin C levels with the presence andseverity of CAD,including the number of stenotic vessels involved and Gensiniscore.Results:Serum cystatin C levels were significantly higher in patients with CAD than those without(P<0.001),and significantly increased as the involvement of coronary vessels/Gensini score increased(P<0.001). Multivariate logistic regression model found Serum cystatin C was an independent factor of CAD.Conclusions:Serum cystatin C levels were significantly associated with the presence and severity of CAD in patients with normal renal function.