复方利多卡因泰唑含漱缓解急诊牙龈疼痛的临床效果

Effect of CompositelidocaineMetronidazole Mouthwash to Relieve Acute Pain of Gingiva in Emergency

目的:探讨含漱复方利多卡因泰唑(甲硝唑漱口液)缓解急诊牙龈疼痛的临床效果。方法:72例急诊牙龈疼痛患者采用分层随机分组、单盲、交叉、自身对照的方法,按照含漱复方利多卡因泰唑、泰唑、0.9%氯化钠溶液,分为观察组、泰唑组和对照组各24例。采用视觉模拟评分量表(VAS)评定患者就诊时、含漱10ml药剂10 min后即刻、30 min、1 h、6 h、12 h、24 h的疼痛分值。结果:三组患者在含漱前VAS值无明显差异(P=0.845);在含漱结束后即刻,观察组的VAS值均明显低于泰唑组和对照组(P<0.05),而泰唑组和对照组无明显差异(P=0.081)。含漱后30 min和1 h,观察组VAS值均低于相应泰唑组(P<0.05),且观察组和泰唑组的VAS值均低于相应对照组(P<0.05);在含漱结束后6 h、12 h,观察组VAS值和泰唑组均低于相应对照组(P<0.05),而观察组和泰唑组无明显差异(P值分别为0.594和0.324);在24 h时,观察组VAS值和泰唑组无明显差异(P=0.381),均小于相应对照组(P<0.05)。结论:复方利多卡因泰唑用于缓解急诊牙龈疼痛效果好,且起效快、安全、便捷。

Objective:To investigate the efficacy of compositelidocaine metronidazole mouthwash in relieving acute pain of gingiva in emergency.Methods:72 patients withacute gingival pain in emergency were stratified by genders and then randomly assigned to observation group,metronidazole group and control group(24 cases in each group).Visual analogue scale(VAS)was used to record and analyze the pain degree before and after 10 ml solutionmouthwashingfor 10 minutes within 24 hours.Results:VAS scores of all three groups of patients before mouthwashing had no significantly difference(P=0.845).And the VAS score of observation group the moment right after mouthwashing was lower than both metronidazole group and control group(P<0.05),but metronidazole group had no significantly difference with control group(P=0.081).VAS scores of both 30 minutes and 1 hour after mouthwashing of the observation group were lower than metronidazole group(P<0.05),and both the observation group and the metronidazole group were lower than the control group(P<0.05).When 6 hours as well as 12 hours after mouthwashing,the VAS scores of the observation group had no difference with metronidazole group(P were 0.594 and 0.324 in accordance),while they were lower than control group accordingly(P<0.05).At the 24 th hour after mouthwashing,the VAS score of the observation group had no statically difference with the metronidazole group(P=0.381),but they were both lower than the score of control group(P<0.05).Conclusions The composite lidocaine metronidazole mouthwash provides a safe,reliable and fast effect in relieving acute gingival pain in emergency.