Ⅱ型猪圆环病毒感染的病理组织学研究进展及疾病诊断

Progress on Histopathology and Diagnostics of Porcine circovirus Type 2

猪圆环病毒Ⅱ型(Porcine circovirus type 2,PCV2)是一种小的单链DNA病毒,是在猪群中高度流行的一种传染病。与PCV2感染相关的临床疾病包括断奶后多系统衰竭综合征(Postweaning Multisystemic Wasting Disease,PMWS)、肠病、呼吸系统疾病、猪皮炎肾病综合征(Porcine Dermatitis and Nephropathy Syndrome,PDNS)及生殖障碍。虽然这些临床表现累及多个器官系统,但该病毒感染引起的临床症状和器官损伤呈现一定的相同点。目前被广泛接受的是,PCV2包括不同的亚型,其中PCV2a和PCV2b在世界范围中广泛流行。本文将对PCV2感染引起的多器官病理损伤及其诊断作以综述。

Porcine circovirus type 2 (PCV2) is a small single-stranded DNA virus and highly prevalent in the domestic pig population. Diseases associated with PCV2 include postweaning multi-systemic wasting disease (PMWS), enteric disease, respiratory disease, porcine dermatitis and ne-phropathy syndrome (PDNS), and reproductive failure. Although these clinical manifestations in-volve different organ systems, there is considerable overlap in clinical expression and organic damage. It is now widely accepted that PCV2 can be further subdivided into different types. PCV2a and PCV2b are present worldwide prevalent and of greatest importance. This review will focus on PCV2-associated lesions in different organ systems and diagnostic methods.