当归饮子急性毒性实验研究

Experimental Study on Acute Toxicity of Danggui Yinzi

目的:观察当归饮子急性毒性反应和动物死亡情况,测定药物的LD_(50),为临床应用的安全性提供试验依据。方法:采用改良寇氏法测定当归饮子对大鼠的半数致死量(LD_(50))。结果:通过急性毒性预实验和正式实验未能测出当归饮子LD_(50),大鼠急性毒性实验体质量及组织病理切片,无明显病理变化。结论:当归饮子具有较好的安全性,临床用药安全可靠。

Objective:To observe the acute toxicity and animal mortality of Angelica Sinensis and determine the LD50 of the drug and provide the experimental basis for the safety of clinical application.Methods:The modified KOU’s method was used to determine the median lethal dose(LD50) of Angelica Sinensis.Results:The acute toxicity of the experimental body and the histopathological biopsy of the acute toxicity test were not detected by acute toxicity preoperative experiment or formal experiment.There was no obvious pathological change.Conclusion:Angelica has a good,and safe and reliable effect.