摘要
目的:探讨益气养阴通络方对气阴两虚型类风湿关节炎的疗效及安全性。方法:选取气阴两虚型RA患者56例,随机分为治疗组及对照组。治疗组在既往用药基础上口服益气养阴通络方智能颗粒1剂/d,对照组加用免疫调节剂,两组坚持用药12周。对比两组患者治疗前后临床疗效、量表评分及炎性指标。结果:治疗前,两组患者病程、年龄、临床症状等无明显差异;治疗后,治疗组ESSPRI评分、ESSDAI评分、免疫球蛋白、Schirmer I试验、唾液流率及C反应蛋白(CRP)、血沉(ESR)均明显改善,对比差异显著,具有统计学意义(P<0.05),治疗组临床总有效率达88.9%,对比观察组,差异有统计学意义(P<0.05)。结论:益气养阴通络方可以改善气阴两虚型类风湿关节炎患者临床症状及炎性指标,值得临床应用。
Objective:To observe the efficacy and safety of Yiqi Yangyin Tongluo Formula for the patients rheumatoid arthritis of rheumatoid arthritis.Methods:Fifty-six cases of RA with deficiency of Qi and Yin syndrome patients were chosen and using random method were divided into treatment group and control group.The treatment group used oral Yiqi Yangyin Tongluo Formula 100 mL/times,3 times/day,on the basis of previous medication.The control group was treated with immunomodulator.Two groups were treated for 12 weeks.Clinical efficacy,scale score and inflammatory index before and after treatment were contrasted.Results:Before treatment,there was no significant difference between the two groups in the course of disease,age or clinical symptoms.After treatment,the treatment group′s ESSPRI score,ESSDAI score,immunoglobulin,Schirmer I test,salivary flow rate,C reactive protein(CRP)and erythrocyte sedimentation rate(ESR)were significantly improved.The difference was statistically significant(P<0.05).The total effective rate was 88.9%in the treatment group,and the difference was statistically significant(P<0.05).Conclusion:Yiqi Yangyin Tongluo Formula can improve the clinical symptoms and inflammatory indexes of rheumatoid arthritis patients of Qi and Yin deficiency syndrome.It is worthy of clinical application.
作者
孙蓬远
高明利
SUN Pengyuan;GAO Mingli(Department of Rheumatology,The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《辽宁中医杂志》
CAS
2019年第7期1431-1433,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
辽宁省医学高峰建设工程重点科研项目基金资助(200940)
关键词
益气养阴通络方
气阴两虚
类风湿关节炎
疗效观察
Yiqi Yangyin Tongluo Formula
deficiency of Qi and Yin syndrome
rheumatoid arthritis
clinical observation