冠脉内超声影像研究“痰瘀”型冠心病冠脉斑块特征的应用价值与意义

Application Value and Significance of Coronary Atherosclerotic Plaques in Patients with Phlegm Stasis Type of Coronary Artery Disease by Intracoronary Ultrasound Imaging

冠心病是临床常见病与高发病,致残、致死率高。脂代谢异常及血管内皮损伤是目前学术界认可的两个动脉粥样硬化启动机制,病理进程最终导致冠脉斑块形成造成不同程度冠脉内狭窄。其引起的血液黏稠及血液高凝病理状态与中医痰性黏滞、血瘀血行不畅的'痰瘀'理论有相似之处。目前对其中西医理论的内在联系研究尚未完善。利用新技术、新方法从中西医结合的角度识别冠脉斑块性质特点并予以针对性干预,在此基础上进一步指导冠心病患者的风险分层、药物研发、疗效评估及介入治疗评估等,是冠心病防治研究的热点和重点。

Coronary heart disease is a common clinical disease with high morbidity,disability and mortality.Abnormal lipid metabolism and vascular endothelial injury are the two mechanisms of atherosclerosis which are recognized by the academic community.The pathological process leads to the formation of coronary atherosclerotic plaque in different degrees of coronary stenosis.The pathology of blood viscosity and hypercoagulability is similar to the theory of phlegm and blood stasis in TCM.At present,the internal relationship between western medicine theory has not been perfected.On the basis of the combination of traditional Chinese and Western medicine,the characteristics of coronary atherosclerotic plaque and targeted intervention are identified.On this basis,the risk stratification,drug development,evaluation of curative effect and evaluation of interventional therapy are further guided to the research of coronary heart disease,which are the focus and hotspots of the prevention and treatment of coronary heart disease.