子宫内膜异位症合并不孕与体质相关性研究

Correlation between Endometriosis with Infertility and Constitution

目的:探索子宫内膜异位症(EM)合并不孕患者的体质分布规律及与发病的相关性。方法:采用北京中医药大学王琦教授创建的'中医体质量表',对376例EM合并不孕患者(病例组)和376例健康女性(对照组)进行体质研究,并根据中华中医药学会发布的《中医体质分类与判定标准》进行体质分类及判定,应用SPSS 22.0统计软件进行数据分析。结果:病例组中按体质出现频次分布前五位的体质为阳虚质、气虚质、湿热质、气郁质、痰湿质;对照组中按体质出现频次分布前五位的体质为平和质、气虚质、湿热质、阳虚质、痰湿质。而两组间平和质、阳虚质、痰湿质、血瘀质、气郁质比较,差异均有统计学意义(P<0.05)。结论:EM合并不孕患者与健康女性的体质分布上存在有明显不同,相关性分析提示平和质与EM合并不孕的发病呈负相关,阳虚质、痰湿质、血瘀质、气郁质与EM合并不孕发病呈正相关,是其发病的高危体质。

Objective:To explore the distribution of constitution and its relationship with the pathogenesis of endometriosis(EM)with infertility.Methods:Using the'Traditional Chinese Medicine Quality Table'created by Professor WANG Qi from Beijing University of Chinese Medicine,376 EM patients with infertility(case group)and 376 healthy women(control group)were studied for constitution.And classification and judgment of constitution were accorded in the Traditional Chinese Medicine Classification and Judgment Criteria which published by Chinese Medicine Association.SPSS22.0 statistical software was used to analyze the data.Results:In the case group,the top five constitutions with frequency distribution according to physique were Yang-deficiency,Qi-deficiency,damp-heat,Qi-depression and phlegm-dampness.In the control group,the top five constitutions with frequency distribution according to physique were constitution of Yin-Yang harmony,Qi-deficiency,damp-heat,Yang-deficiency and phlegm-dampness.There was significant difference between the two groups in Yin-Yang harmony,Yang-deficiency,phlegm-dampness,blood stasis and Qi-depression(P<0.05).Conclusion:There is significant difference in the constitution distribution of EM with infertility patients and healthy women.Correlation analysis showed that constitution of Yin-Yang harmony was negatively correlated to the pathogenesis of EM with infertility.Yang-deficiency,phlegm-dampness,blood stasis and Qi-depression were positively correlated to the pathogenesis of EM with infertility and are the high-risk constitutions of the disease.