基于辅助生殖技术新生儿胎黄中医证型的研究

Clinical Abservation on Traditional Chinese Medicine Types of Neonatal Jaundice in Neonates Conceived after Assisted Reproduction

目的:通过观察辅助生殖技术(ART)出生的新生儿胎黄证型的分布特点,从中医学角度初步探讨ART对新生儿健康风险的影响。方法:选取2017年8月1日—2017年12月31日出生的34例ART助孕分娩的健康足月单胎新生儿为观察组,54例同期自然妊娠(NC)分娩的健康足月单胎新生儿为对照组,比较两组胎黄证型的分布。结果:两组新生儿胎黄证型分布存在统计学差异(P<0.05);ART是阴黄发生的危险因素(OR=2.481,OR 95%CI:1.003-6.137)。结论:阳黄为ART新生儿胎黄的主要证型,ART新生儿阴黄占比较NC新生儿增加。ART过程施加的理化刺激、环境差异及母亲体质遗传背景可能为阴黄证型提供寒、瘀、胎禀不足等发病基础。

Objective:To explore the effects of assisted reproductive technology(ART)on neonatal health risks from the perspective of TCM,by observing TCM types of neonatal jaundice.Methods:The paper investigated 92 healthy newborns,single birth and rooming-in,in a hospital between Aug and Dec 2017[34 ART,58 NC].Results:There were statistically significant differences in TCM syndrome types of neonatal jaundice when grouped by pregnancy way.ART was a risk factor for Yin jaundice(OR=2.481,OR95%CI:1.003-6.137).Conclusion:Yang jaundice was the main TCM type in both groups,but ART-conceived newborns were significantly more likely than NC newborns to be Yin jaundice.ART increased the incidence of cold syndrome,deficiency syndrome and stasis syndrome for newborns,because of physical and chemical stimulations,the differences between in vivo and in vitro environment in its process,also the low fertility.