滋阴疏肝法对围绝经期综合征患者性激素水平及KI评分的影响及疗效观察

Effect and Curative Effect of Tonifying Yin and Soothing Liver Therapy on Sexual Hormone Level and KI Score in Patients with Perimenopause Syndrome

目的:探讨滋阴疏肝法对围绝经期综合征患者性激素水平及KI评分影响及疗效研究。方法:选取2016年1月—2018年1月本院收治的围绝经期综合征患者80例,采用随机数字表法分为对照组(40例)和观察组(40例)。对照组患者给予芬吗通治疗,观察组用滋阴疏肝法治疗。比较两组治疗1个疗程后的临床疗效,同时比较两组治疗前后d的Kupperman评分(KI),肝肾功能指标水平,血清促黄体素(LH)、雌二醇(E2)及促卵泡激素(LH)水平,比较两组治疗期间不良反应发生情况。结果:观察组总有效率为85. 00%,对照组治疗总有效率为75. 00%,两组治疗总有效率差异无统计学意义(P> 0. 05);治疗后观察组KI评分显著低于对照组;治疗后观察组LH、FSH水平显著低于对照组,E2水平显著高于对照组,差异具有统计学意义(P <0. 05);治疗前及治疗后两组患者ALT、AST及BUN水平比较差异无统计学意义(P> 0. 05);观察组不良反应发生率显著低于对照组,差异具有统计学意义(P=0. 02,χ2=5. 00)。结论:滋阴疏肝法可有效治疗围绝经期综合征,改善患者临床症状及卵巢功能,同时不影响患者肝肾功能,不良反应发生率更低,值得临床推广使用。

Objective:To explore the effect of nourishing Yin and soothing liver method on sex hormone level and KI score in patients with perimenopause syndrome.Methods:From January 2016 to January 2018,80 patients with perimenopause syndrome were randomly divided into control group(n=40)and observation group(n=40).The patients in the control group were treated with phenolactone,and the observation group were treated with nourishing Yin and soothing the liver.We compared the clinical efficacy of two groups after one course of treatment and the levels of Kupperman score(KI),liver and kidney function index,serum luteinizing hormone(LH),estradiol(E2)and follicle stimulating hormone level(LH)before and after treatment in the two groups before and after treatment.The incidence of adverse reactions during treatment was compared between the two groups.Results:The total effective rate was 85.00%in the observation group and 75.00%in the control group.There was no significant difference in the total effective rate between the two groups(P>0.05).After treatment,the KI score in the observation group was significantly lower than that in the control group.The levels of LH and FSH in the observation group were significantly lower than those in the control group,while the level of E2 was significantly higher than that in the control group(P<0.05).There was no significant difference in the levels of ALT,AST or BUN between the two groups before and after treatment(P>0.05).The incidence of adverse reactions in observation group was significantly lower than that in control group and the difference was statistically significant(P=0.02,χ2=5.00).Conclusion:The method of nourishing Yin and soothing the liver can effectively treat the perimenopause syndrome,improve the clinical symptoms and ovarian function of the patients,without affecting the function of the liver and kidney of the patients,and the incidence of adverse reactions is lower,so it is worthy of popularizing and using in clinic.