针刺联合西格列汀对肥胖2型糖尿病患者脂联素、adropin及irisin的影响

Effect of Acupuncture Combined with Sitagliptin on Obese Patients with Type 2 Diabetes and its Effect on Adiponectin,Adropin and Irisin

目的:探讨针刺联合西格列汀对肥胖2型糖尿病患者脂联素、adropin及irisin的影响。方法:选取肥胖2型糖尿病患者60例,随机分成对照组和针刺组,每组30例。两组均予西格列汀口服,针刺组加予针刺治疗。比较两组糖脂代谢,血清脂联素、adropin及irisin治疗前后差异。结果:针刺组总有效率(90. 00%)高于对照组(63. 33%)(P <0. 05);两组治疗后FPG、2hPG、HbA1c降低(P <0. 05);治疗后,针刺组FPG、2hPG、HbA1c低于对照组(P <0. 05);两组治疗后TG、TC均降低(P <0. 05),针刺组治疗后BMI、LDL降低,HDL升高(P <0. 05);针刺组经治疗后BMI、TG、TC低于对照组(P <0. 05),HDL高于对照组(P <0. 05)。治疗后两组脂联素水平均升高(P <0. 05),针刺组脂联素水平较对照组升高更明显(P <0. 05)。对照组治疗前后adropin、irisin无统计学差异(P> 0. 05);针刺组治疗后的adropin及irisin均高于同组治疗前水平(P <0. 05);经治疗后,针刺组adropin、irisin均高于对照组(P <0. 05)。针刺组不良反应发生率(6. 66%)低于对照组(16. 67%),但无统计学差异(P> 0. 05)。结论:针刺联合西格列汀治疗肥胖糖尿病患者疗效显著,改善糖脂代谢及提升脂联素更具优势。针刺可刺激机体产生adropin及irisin。

Objective:To observe the effect of acupuncture combined with Sitagliptin on adiponectin,adropin,irisin and glycolipids metabolism in patients with type 2 diabetes.Methods:Sixty obese patients with type 2 diabetes were randomly divided into the control group and the acupuncture group,30 cases in each.Both of the two groups were treated with Sitagliptin orally.The acupuncture group added acupuncture.Glycolipids,adiponectin,adropin and irisin were compared between the two groups.Results:The total effective rate of the acupuncture group(90%)was higher than that of the control group(63.33%).After treatment,FPG,2 hPG and HbA1c in both groups were reduced(P<0.05).FPG,2 hPG and HbA1c in acupuncture group were lower than those in the control group(P<0.05).TG and TC were decreased in both two groups(P<0.05).BMI and LDL were reduced and HDL was raised in the acupuncture group(P<0.05).BMI,TG and TC in the acupuncture group were lower than those in the control group(P<0.05).HDL was higher than that of the control group(P<0.05).The levels of adiponectin in both two groups increased after treatment,while the level of adiponectin in the acupuncture group was higher than that in the control group.There was no statistical difference between the levels of adropin and irisin before and after treatment in the control group(P>0.05).After treatment,the levels of adropin and irisin in acupuncture group increased(P<0.05)and were higher than those in the control group(P<0.05).The incidence of adverse reactions in the acupuncture group(6.66%)was lower than that in the control group(16.67%),but there was no significant difference(P>0.05).Conclusion:Acupuncture combined with Sitagliptin has significant therapeutic effect on obese patients with type 2 diabetes.This treatment has more advantages in improving adiponectin,glucose and lipid metabolism.Acupuncture may stimulate human body to produce adropin and irisin.