三种贯叶连翘组药用植物醇提物对小鼠的抗抑郁作用

Antidepressant Effect of Ethanol Extracts from Three Species of Sect. Hypericum Medicinal Plants in Mice

目的:对贯叶连翘组药用植物的抗抑郁作用进行研究,为筛选新的药用品种以及对其品质评价提供药效学依据。方法:采用小鼠尾悬挂试验、小鼠强迫游泳试验抑郁模型对三种贯叶连翘组药用植物醇提物的抗抑郁作用进行研究。结果:在小鼠尾悬挂试验、小鼠强迫游泳试验中,元宝草和扬子小连翘醇提物与贯叶连翘一样,可以对抗小鼠的失望行为,使实验动物的绝望时间(不动时间)缩短,具有抗抑郁作用,但是贯叶连翘醇提物的抗抑郁作用明显强于扬子小连翘。结论:三种川产贯叶连翘组药用植物醇提物在行为绝望动物模型上有明显的抗抑郁作用。

Objective:To explore the antidepressant actions of ethanol extracts from three species of sect. Hypericum medicinal plants. Methods:The forced swimming test and mouse tail suspensions in mice were used. Result:Ethanol extracts of sect. Hypericum medicinal plants significantly shortened motionless time of mice forced swimming and despair time of mouse tail suspension in the two behavior despair animal models of depression. The effect of H. faberi was weaker than that of H. perforatum. Conclusion:These findings demonstrated that the extracts from three species of sect. Hypericum medicinal plants possessed obvious antidepressant activity.