银杏叶制剂对体外授精治疗中卵巢反应低下患者的作用

Effect of Ginkgo Leaf Preparation on Patients with Poor Ovarian Response to Extracorporeal Fertilization

目的:探讨银杏叶制剂对助孕技术治疗中卵巢反应低下患者的临床疗效。方法:38例卵巢反应低下患者,按完全随机的方法分为两组,治疗组进行为期2个月经周期的银杏叶制剂治疗,对照组不经过任何治疗,歇息≥2个月经周期,两组均再次行控制性超排卵人工助孕治疗。结果:两组(治疗组和对照组)治疗后在激素用量、激素的治疗天数和每天的激素安瓿数方面比较差异无显著性,而E_2水平(ng/L,1750±731与1134±485)、卵泡数(个,5.3±2.2与1.6±0.7)、卵细胞数(个,4.2 ±1.8与1.7±0.6)、子宫内膜厚度(mm,9.5±1.1与8.3±1.7)两组间的差异均有显著性(P<0.05),子宫动脉搏动指数和卵巢动脉搏动指数有所改善,但差异无显著性。治疗组临床妊娠率为15.8％(3/19例)。结论:银杏叶制剂能增加卵巢反应低下患者在助孕技术治疗中的卵泡和卵细胞的数量,改善子宫内膜厚度,提高临床妊娠率。

Objective: To investigate the clinical effect of Ginkgo leaf preparation (GLP) on patients with poor ovarian response to assisted reproductive technology. Methods; Thirty-eight patients who showed poor ovarian response to extracorporeal fertilization were randomly divided into two groups, the treated group was treated with GLP for 2 menstrual cycles, the control group was un-treated. They were undertaken the artificial assisted reproductive technology with controlled ovarian hyperstimulation treatment 2 months later again. Results: The two groups showed insignificant difference in amount of gonadotropic hormone, treatment days and daily dosage of hormone used, but it showed significant difference (P<0,05) in blood estradiol (1750±731 ng/L vs 1134±485), number of follicles (5.3±2.2vsl.6±0.7), number of oocytes (4.2±1. 8 vs 1. 7±0. 6) and endome-trial thickness (0.95±0.11 vs0.83±0.17). The pulsatility index of the uterine artery and the ovarian artery after treatment improved but with no significant difference in comparing with those in the control group. The pregnancy rate in the treated group was 15.8% (3/19). Conclusion: GLP can increase the numbers of follicle and oocyte as well as the endometrial thickness to elevate pregnancy rate in poor ovarian responder to assist reproduction technology treatment.