日本血吸虫新基因的发现及其功能的初步预测

Discovery of novel Schistosoma japonicum genes by EST strategy and indentification by bioinformatics

本文运用表达序列标签（expressed sequence tags,EST）法筛选日本血吸虫（中国大陆株）成虫cD-NA文库,获得50个日本血吸虫EST片段,经过测序后将EST序列送入EMBL和NCBI、Genbank进行同源性分析并登录。为寻找新的抗血吸虫疫苗候选分子、化疗药物及具有我国自主知识产权的血吸虫功能基因奠定工作基础。

To identify novel Schistosoma japonicum(S.j) for new vaccine candidates and drug targets, 50 ESTs have been generated from S. j adult cDNA libray. And further analyses according to bioinformatics were made. 9 of 50 S. j EST have homology with identified schistosoma mansoni and other organisms.