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HPV E6/E7 mRNA联合HPV L1衣壳蛋白在子宫颈癌前病变诊断中的价值 被引量：17

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摘要 目的探讨HPV E6/E7 mRNA联合HPV L1衣壳蛋白检测在子宫颈癌前病变诊断中的价值。方法采用分支链DNA信号放大技术检测156例子宫颈活检不同病变组织中HPV E6/E7 mRNA的表达,并应用免疫组化En Vision法检测HPV L1衣壳蛋白的表达。结果与正常组织相比,子宫颈低级别上皮内病变(low-grade squamous intraepithelial lesion,LSIL)、子宫颈高级别上皮内病变(high-grade squamous intraepithelial lesion,HSIL)和子宫颈鳞癌组织中HPV E6/E7mRNA的阳性率增高(P <0. 05),且HSIL和子宫颈癌中HPV E6/E7 mRNA的阳性率高于LSIL(P <0. 05),但HSIL和子宫颈癌组织中HPV E6/E7 mRNA的阳性率差异无显著性(P> 0. 05); HPV L1衣壳蛋白在LSIL中的阳性率明显高于HSIL(P <0. 05)。结论通过对子宫颈不同病变标本进行HPV E6/E7 mRNA和HPV L1衣壳蛋白联合检测,了解不同病变子宫颈组织中HPV E6/E7 mRNA和HPV L1衣壳蛋白的表达趋势,可预测子宫颈上皮内病变的发展趋势,指导临床医师进行合理治疗。
作者 田智丹 王劲松 黄文斌
机构地区 南京医科大学附属南京医院(南京市第一医院)病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2019年第3期351-353,共3页 Chinese Journal of Clinical and Experimental Pathology
关键词 子宫颈肿瘤 子宫颈上皮内瘤变 人乳头状瘤病毒 HPV E6/E7 HPV L1
分类号 R737.33 [医药卫生—肿瘤]
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参考文献3

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  • 1Whitlock EP, Vesco KK, Eder M, et al. Liquid-based cytology and human papillomavirus testing to screen for cervical cancer: a systematic review for the U.S. Preventive Services Task Force[J]. Ann Intern Med, 2011, 155(10): 687-697.
  • 2Franceschi S, Denny L, Irwin KL, et al. Eurogin 2010 roadmap on cervical cancer prevention[J]. Int J Cancer, 2011, 128(12):2765-2774.
  • 3Hilfrich R, Hariri J. Prognostic relevance of human papillomavirus L1 capsid protein detection within mild and moderate dysplastic lesions of the cervix uteri in combination with p16 biomarker[J]. Anal Quant Cytol Histol, 2008, 30(2): 78-82.
  • 4Lee SJ, Lee AW, Kang CS, et al. Clinicopathological implications of human papilloma virus (HPV) L1 capsid protein immunoreactivity in HPV 16-positive cervical cytology [J]. Int J Med Sci, 2013, 11(1):80-86.
  • 5Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology [J]. JAMA, 2002, 287(16):2114-2119.
  • 6Darragh TM, Colgan TJ, Thomas Cox J, et al. The Lower Anogenital Squamous Terminology Standardization project for HPV-associated lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology[J]. Int J Gynecol Pathol, 2013, 32(1):76-115.
  • 7Siddiqui MT, Hornaman K, Cohen C, et al. ProEx C immunocytochemistry and high-risk human papillomavirus DNA testing in papanicolaou tests with atypical squamous cell (ASC-US) cytology: correlation study with histologic biopsy[J]. Arch Pathol Lab Med, 2008, 132(10): 1648-1652.
  • 8Griesser H, Sander H, Hilfrich R, et al. Correlation of immunochemical detection of HPV L1 capsid protein in pap smears with regression of high-risk HPV positive mild/ moderate dysplasia[J]. Anal Quant Cytol Histol, 2004, 26(5): 241-245.
  • 9Yoshida T, Sano T, Kanuma T, et al. Immunochemieal analysis of HPV L1 capsid protein and p16 protein in liquid-based cytology samples from uterine cervical lesions [J]. Cancer, 2008, 114(2):83-88.
  • 10Ho C M, Lee B H, Chang S F, et al. Integration of human papillomavirus correlates with high levels of viral oncogene transcripts in cervical carcinogenesis [J].Virus Res, 2011,161 ( 2 ) : 124 - 30.

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临床与实验病理学杂志
2019年 第3期

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