摘要
目的 研究银屑病环境危险因素与HLA DQA1等位基因交互作用。方法 采用病例 对照方法调查 176例银屑病患者及 185例健康人环境因素 ,用PCR SSP方法检测HLA DQA1等位基因 ;对环境危险因素与HLA DQA1等位基因交互作用进行研究。结果 ①在有及无家族史银屑病中 ,HLA DQA1 0 10 4与受潮存在交互作用 (P <0 .0 5 ,OR>4.0 ) ;在无家族史银屑病中HLA DQA1 0 10 4与饮酒 (P =0 .0 190 ,OR =4.62 )、食鱼虾 (P =0 .0 42 6,OR =2 .82 )存在交互作用。②HLA DQA1 0 2 0 1与食鱼虾 (P =0 .0 0 74,OR =4.72 )仅在无家族史银屑病中存在交互作用。③HLA DQA1 0 5 0 1与受潮 (P =0 .0 0 40 ,OR =10 .5 0 )、食鱼虾 (P =0 .0 3 3 8,OR =5 .41)和精神紧张 (P =0 .0 482 ,OR =8.14 )仅在有家族史银屑病中存在交互作用。结论 HLA DQA1等位基因能增加银屑病环境危险因素发生该病的危险性 ,在有及无家族史银屑病中存在差异。
Objective To study the HLA-DQA1*0104,DQA1*0201,DQA1*0501 alleles and environment interaction in psoriasis.Methods Using case-control study.176 psoriatic and 185 healthy people were investigated.The HLA-DQA1*0104,DQA1*0201 and DQA1*0501 alleles were examined by PCR-SSP.Results ①The HLA-DQA1*0104 allele and moisture were interacion in both familial and non-familial psoriasis(P<0.05,OR>4.0).The HLA-DQA1*0104 allele,drinking(P=0.0190,OR=4.62) and eating fish and shrimp(P=0.0426,OR=2.82) were interaction in non-familial psoriasis.②The HLA-DQA1*0201 allele and eating fish and shrimp(P=0.0074,OR=4.72) were interaction in non-familial psoriasis.③The HLA-DQA1*0501 allele,moisture(P=0.0040,OR=10.50),eating fish and shrimp(P=0.0338,OR=5.41) and stress(P=0.0482,OR=8.14) were interaction in familial psoriasis.Conclusion The HLA-DQA1*0104,DQA1*0201 and DQA1*0501 alleles improved risk possibility of environmental factors in psoriasis.There was difference of gene-environmental interaction between familial and non-familial psoriasis.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2003年第2期82-84,98,共4页
The Chinese Journal of Dermatovenereology
基金
国家 8 63资助研究项目 (Z - 1 9- 0 1 - 0 4 - 0 4 )
安徽省自然科学基金项目 (990 4 4 2 37)