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有无家族史银屑病环境因素与HLA-DQA1等位基因交互作用的研究 被引量:1

Study of HLA-DQA1 Genes and Environmental Risk Factors Interaction in Familial and non-Familial Psoriasis
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摘要 目的 研究银屑病环境危险因素与HLA DQA1等位基因交互作用。方法 采用病例 对照方法调查 176例银屑病患者及 185例健康人环境因素 ,用PCR SSP方法检测HLA DQA1等位基因 ;对环境危险因素与HLA DQA1等位基因交互作用进行研究。结果 ①在有及无家族史银屑病中 ,HLA DQA1 0 10 4与受潮存在交互作用 (P <0 .0 5 ,OR>4.0 ) ;在无家族史银屑病中HLA DQA1 0 10 4与饮酒 (P =0 .0 190 ,OR =4.62 )、食鱼虾 (P =0 .0 42 6,OR =2 .82 )存在交互作用。②HLA DQA1 0 2 0 1与食鱼虾 (P =0 .0 0 74,OR =4.72 )仅在无家族史银屑病中存在交互作用。③HLA DQA1 0 5 0 1与受潮 (P =0 .0 0 40 ,OR =10 .5 0 )、食鱼虾 (P =0 .0 3 3 8,OR =5 .41)和精神紧张 (P =0 .0 482 ,OR =8.14 )仅在有家族史银屑病中存在交互作用。结论 HLA DQA1等位基因能增加银屑病环境危险因素发生该病的危险性 ,在有及无家族史银屑病中存在差异。 Objective To study the HLA-DQA1*0104,DQA1*0201,DQA1*0501 alleles and environment interaction in psoriasis.Methods Using case-control study.176 psoriatic and 185 healthy people were investigated.The HLA-DQA1*0104,DQA1*0201 and DQA1*0501 alleles were examined by PCR-SSP.Results ①The HLA-DQA1*0104 allele and moisture were interacion in both familial and non-familial psoriasis(P<0.05,OR>4.0).The HLA-DQA1*0104 allele,drinking(P=0.0190,OR=4.62) and eating fish and shrimp(P=0.0426,OR=2.82) were interaction in non-familial psoriasis.②The HLA-DQA1*0201 allele and eating fish and shrimp(P=0.0074,OR=4.72) were interaction in non-familial psoriasis.③The HLA-DQA1*0501 allele,moisture(P=0.0040,OR=10.50),eating fish and shrimp(P=0.0338,OR=5.41) and stress(P=0.0482,OR=8.14) were interaction in familial psoriasis.Conclusion The HLA-DQA1*0104,DQA1*0201 and DQA1*0501 alleles improved risk possibility of environmental factors in psoriasis.There was difference of gene-environmental interaction between familial and non-familial psoriasis.
出处 《中国皮肤性病学杂志》 CAS 北大核心 2003年第2期82-84,98,共4页 The Chinese Journal of Dermatovenereology
基金 国家 8 63资助研究项目 (Z - 1 9- 0 1 - 0 4 - 0 4 ) 安徽省自然科学基金项目 (990 4 4 2 37)
关键词 银屑病 环境因素 HLA-DQAl 等位基因 交互作用 研究 Psoriasis Risk factors HLA-DQA1 alleles Interaction
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  • 1Millard TP, Bataille V, Snieder H, et al. The heritability of polymorphie light eruption [J]. J Invest Dermatol, 2000,115 ( 3 ) :467 - 470.
  • 2Mcgregor JM, Grabczynska S, Vaughan R, et al. Genetic modeling of abnormal photosensitivity in families with polymorphic light eruption and actinic prurigo[ J ]. J Invest Dcrmatol, 2000, 115 ( 3 ):471 - 476.
  • 3Naleway AL. Polymorphous light eruption [ J ]. Int J Dermatol, 2002,41 (7) :377 -383.
  • 4Millard TP, Fryer AA, Mcgregor JM. A protective effect of glutathione-transferase GSTP1 * Val(105) against polymorphic light eruption[J]. J Invest Dermato|,2008,128 ( 8 ) : 1901 - 1905.
  • 5Taylor JA, Umbach DM, Stephens E, et al. The role of N-acetylation polymorphisms in smoking-associated bladder cancer: evidence of a gene gene-exposure three-way interaction [ J ]. Cancer Research, 1998,58(16) :3603 - 3610.
  • 6Porta M, Malats N, Guarner L, et al. Association between coifee drinking and K-ras mutations in exocrine panereatic cancer [J]. J Epidemiol Community Health, 1999,53( 11 ) :702 - 709.
  • 7杨成,何黎,杨小燕,张丽.多形性日光疹110例临床及危险因素分析[J].中国皮肤性病学杂志,2012,26(3):224-225. 被引量:7
  • 8杨成,何黎,杨小燕,涂颖,吴文娟,邹菥,庞勤.HLA-DQB1等位基因与云南汉族多形性日光疹易感性的相关性[J].中国皮肤性病学杂志,2013,27(5):454-457. 被引量:3

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