低分子肝素治疗不稳定型心绞痛疗效观察

Efficacy of Low Molecular Weight Heparin in Treatment of Unstable Angina Pectoris

目的 :观察低分子肝素 (LMWH)治疗不稳定型心绞痛 (UAP)的疗效及安全性。方法 :76例UAP随机分成低分子肝素加阿司匹林为治疗组和安慰剂加阿司匹林为对照组。治疗组用低分子肝素 0 .4m1皮下注射 2次 /d× 7d。对照组生理盐水 (NS) 0 .4m1皮下注射 2次 /d× 7d。两组病人每天均服用 10 0mg阿司匹林以及接受常规抗心绞痛治疗。结果 :低分子肝素加阿司匹林治疗后病人的临床症状和心电图改善均明显优于安慰剂加阿司匹林 (P <0 .0 1) ,且治疗组治疗后血液流变学主要指标较对照组显著改善 (P<0 .0 5 )。结论 :以低分子肝素治疗不稳定型心绞痛疗效更有效安全 ,无明显不良反应。

Objective: To study the efficacy of low molecular weight heparin (LMWH) plus aspirin in treatment of unstable angina pectoris (UAP). Methods: 96 patients were randomly divided into LMWH plus aspirin treatment group and placebo plus aspirin control group.40 patients with UAP were treated with subcutaneous injection of fraxiparine (0.4 ml) twice per day for consecutive 7 days;36 patients were treated subcutaneous injection of with NS 0.4 ml twice per day for 7 consecutive days;and all patients were treated with aspirin, nitroglycerin, β blocker, Calcium channel blocking agent and ACEI.Results: The improvements of clinical symptoms and ECG in UAP patients treated with LMWH plus aspirin were greater than those in patients treated with placebo plus aspirin. There was significant difference between two groups ( P <0.01). Mean while the improvements of some quotas in hemorrheology in UAP patients treated with LMWH plus aspirin were greater than those in patients with placebo plus aspirin. There was significant difference between two groups( P <0.05). Conclusion: The treatment of LMWH plus aspirin was more effective in UAP patients.