心力衰竭患者可溶性细胞间粘附分子-1的变化及意义

Changes and Significance of the Soluble Intercellular Adhesion Molecule-1 in Patients with Heart Failure

目的 :探讨可溶性细胞间粘附分子 1(SICAM 1)与充血性心力衰竭 (CHF)的关系。方法 :心衰患者 45例和年龄相匹配的对照组 2 0例。测定血清SICAM 1、白介素 6(IL 6)、肿瘤坏死因子 α(TNF α)、血浆内皮素 1(ET 1)等 ,SICAM 1用ELISA检测 ,IL 6、TNF α、ET 1用放射免疫法检测。结果 :CHF患者血清SICAM 1、IL 6、TNF α、血浆ET 1浓度较对照组明显升高 (分别为P <0 .0 0 1、0 .0 0 1、0 .0 5、0 .0 1)。血清SICAM 1与血清IL 6呈正相关 (r =0 .45 11,P <0 .0 1) ,与血浆ET 1也呈正相关 (r =0 .4179,P <0 .0 1)。结论 :细胞间粘附分子 1在充血性心力衰竭中的作用可能与免疫功能激活及内皮损伤有关。

Objective:To study the changes of the serum soluble intercellular adhesion molecule 1(SICAM 1)and its correlation with congestive heart failure(CHF).Methods:Serum SICAM 1,Tumor Necrosis Factor alpha(TNF α),Interleukin 6(IL 6),plasma Endothelium 1(ET 1) were measured in 45 patients with CHF and 20 age matched control patients. SICAM 1 was measured by Enzyme linked immunosorbent assay,and TNF α,IL 6,ET 1 by radio immunology assay. Results:The levels of SICAM 1, TNF α, IL 6,and ET 1 were significantly elevated in patients with CHF as compared with control group. SICAM 1 was positively correlated with IL 6 ( r =0.4511, P <0.01),and with ET 1( r =0.4179, P <0.01).Conclusion:The role of SICAM 1 in the pathogenesis of CHF may correlate with immune activation and endothelium dysfunction.