盐酸纳洛酮治疗急性重症脑外伤的临床研究

Clinical use of Naloxone for acute severe brain injuries

目的 :探讨盐酸纳洛酮在急性重型颅脑外伤中的应用效果及其机制。方法 :选择GCS 5～ 8分患者 5 6例每天应用盐酸纳洛酮 4.0mg ,随机以 5 6例同等伤情未用盐酸纳洛酮药物治疗病例为对照组。观察意识觉醒、临床征象等。结果 :觉醒天数缩短 ,死亡率和致残率减少。结论 :盐酸纳洛酮对于内源性阿片肽引起的生理功能的应急性疾病起效快、作用可靠 ,其使用安全 ,治疗过程中未见有毒副作用。

Objective:To discuss the clinical effects and mechanism of Naloxone for acute severe brain injuries. Methods:112 patients (GCS 5～8) were randomly assigned into two groups.56 patients had been treated on routine and other 56 patients had been treated with Naloxone.The consciousness and clinical features of the two groups were compared. Results:The time of awakening and conscious recovery in treatment group were shortener than that in control.The mortality and disability rate were cut down in treatment group. Conclusion:As a specific opioid receptor antagonist,Naloxone is safe and effective in treatment of post injury pathophysiologic changes due to endogenous opioid peptides in stress. Moreover, no side effects and long dated comlications were found.