慢性萎缩性胃炎胃粘膜活检材料的电镜观察

Electron Microscopic Observation of Gastric Biopsies from Chronic Atrophic Gastritis

本文对175例慢性萎缩性胃炎胃幽门部粘膜活检材料进行了电镜观察,发现由于表面粘膜上皮和腺上皮细胞的变化,间隙的增宽,幽门螺旋菌的破坏,从而导致胃粘膜屏障功能的减弱,肠上皮化生,不典型增生及化生灶内上皮细胞的双向分化现象。从形态学上进一步支持了慢性萎缩性胃炎是重要的癌前病变这一学说。

Gastric biopsies from 175 cases of chronic atrophic gastritis in the pylorus region were observed by transmission electron microscopy. The decreasing of barrier function of mucous membrane, the edema cell spaces, the helicobacteria pylorus destruction resulting in the change of mucous membrane and glandular epithelial cells, and double differentiated cell in the region of intestinal metaplasia were found. The results suport further that chronic atrophic gastritis is an important origin of carcinoma in the morphology.